Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 1172843

A pooled analysis of molecular epidemiological studies on modulation of DNA repair by host factors


(hCOMET Cost akcija CA15132) Opattova, Alena; Langie, Sabine A.S.; Milic, Mirta; Collins, Andrew; Brevik, Asgeir; Coskun, Erdem; Dusinska, Maria; Gaivão, Isabel; Kadioglu, Ela; Laffon, Blanca et al.
A pooled analysis of molecular epidemiological studies on modulation of DNA repair by host factors // Mutation research. Genetic toxicology and environmental mutagenesis, 1 (2022), 503447, 29 doi:10.1016/j.mrgentox.2022.503447 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1172843 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
A pooled analysis of molecular epidemiological studies on modulation of DNA repair by host factors

Autori
Opattova, Alena ; Langie, Sabine A.S. ; Milic, Mirta ; Collins, Andrew ; Brevik, Asgeir ; Coskun, Erdem ; Dusinska, Maria ; Gaivão, Isabel ; Kadioglu, Ela ; Laffon, Blanca ; Marcos, Ricard ; Pastor, Susana ; Slyskova, Jana ; Smolkova, Bozena ; Szilágyi, Zsófia ; Valdiglesias, Vanessa ; Vodicka, Pavel ; Volkovova, Katarina ; Bonassi, Stefano ; Godschalk, Roger W.L.

Kolaboracija
HCOMET Cost akcija CA15132

Izvornik
Mutation research. Genetic toxicology and environmental mutagenesis (1383-5718) 1 (2022); 503447, 29

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
DNA repair ; comet assay ; base excision repair ; oxidatively damaged DNA ; biomarker ; BMI

Sažetak
Levels of DNA damage represent the dynamics between damage formation and removal. Therefore, to better interpret human biomonitoring studies with DNA damage endpoints, an individual’s ability to recognize and properly remove DNA damage should be characterized. Relatively few studies have included DNA repair as a biomarker and therefore, assembling and analyzing a pooled database of studies with data on base excision repair (BER) was one of the goals of hCOMET (EU-COST CA15132). A group of approximately 1911 individuals, was gathered from 8 laboratories which run population studies with the comet-based in vitro DNA repair assay. BER incision activity data were normalized and subsequently correlated with various host factors. BER was found to be significantly higher in women. Although it is generally accepted that age is inversely related to DNA repair, no overall effect of age was found, but sex differences were most pronounced in the oldest quartile (>61 years). No effect of smoking or occupational exposures was found. A body mass index (BMI) above 25 kg/m2 was related to higher levels of BER. However, when BMI exceeded 35 kg/m2, repair incision activity was significantly lower. Finally, higher BER incision activity was related to lower levels of DNA damage detected by the comet assay in combination with formamidopyrimidine DNA glycosylase (Fpg), which is in line with the fact that oxidatively damaged DNA is repaired by BER. These data indicate that BER plays a role in modulating the steady-state level of DNA damage that is detected in molecular epidemiological studies and should therefore be considered as a parallel endpoint in future studies.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita, Interdisciplinarne biotehničke znanosti, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA


Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb

Profili:

Avatar Url Mirta Milić (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com

Citiraj ovu publikaciju:

(hCOMET Cost akcija CA15132) Opattova, Alena; Langie, Sabine A.S.; Milic, Mirta; Collins, Andrew; Brevik, Asgeir; Coskun, Erdem; Dusinska, Maria; Gaivão, Isabel; Kadioglu, Ela; Laffon, Blanca et al.
A pooled analysis of molecular epidemiological studies on modulation of DNA repair by host factors // Mutation research. Genetic toxicology and environmental mutagenesis, 1 (2022), 503447, 29 doi:10.1016/j.mrgentox.2022.503447 (međunarodna recenzija, članak, znanstveni)
(hCOMET Cost akcija CA15132) (hCOMET Cost akcija CA15132) Opattova, A., Langie, S., Milic, M., Collins, A., Brevik, A., Coskun, E., Dusinska, M., Gaivão, I., Kadioglu, E. & Laffon, B. (2022) A pooled analysis of molecular epidemiological studies on modulation of DNA repair by host factors. Mutation research. Genetic toxicology and environmental mutagenesis, 1, 503447, 29 doi:10.1016/j.mrgentox.2022.503447.
@article{article, author = {Opattova, Alena and Langie, Sabine A.S. and Milic, Mirta and Collins, Andrew and Brevik, Asgeir and Coskun, Erdem and Dusinska, Maria and Gaiv\~{a}o, Isabel and Kadioglu, Ela and Laffon, Blanca and Marcos, Ricard and Pastor, Susana and Slyskova, Jana and Smolkova, Bozena and Szil\'{a}gyi, Zs\'{o}fia and Valdiglesias, Vanessa and Vodicka, Pavel and Volkovova, Katarina and Bonassi, Stefano and Godschalk, Roger W.L.}, year = {2022}, pages = {29}, DOI = {10.1016/j.mrgentox.2022.503447}, chapter = {503447}, keywords = {DNA repair, comet assay, base excision repair, oxidatively damaged DNA, biomarker, BMI}, journal = {Mutation research. Genetic toxicology and environmental mutagenesis}, doi = {10.1016/j.mrgentox.2022.503447}, volume = {1}, issn = {1383-5718}, title = {A pooled analysis of molecular epidemiological studies on modulation of DNA repair by host factors}, keyword = {DNA repair, comet assay, base excision repair, oxidatively damaged DNA, biomarker, BMI}, chapternumber = {503447} }
@article{article, author = {Opattova, Alena and Langie, Sabine A.S. and Milic, Mirta and Collins, Andrew and Brevik, Asgeir and Coskun, Erdem and Dusinska, Maria and Gaiv\~{a}o, Isabel and Kadioglu, Ela and Laffon, Blanca and Marcos, Ricard and Pastor, Susana and Slyskova, Jana and Smolkova, Bozena and Szil\'{a}gyi, Zs\'{o}fia and Valdiglesias, Vanessa and Vodicka, Pavel and Volkovova, Katarina and Bonassi, Stefano and Godschalk, Roger W.L.}, year = {2022}, pages = {29}, DOI = {10.1016/j.mrgentox.2022.503447}, chapter = {503447}, keywords = {DNA repair, comet assay, base excision repair, oxidatively damaged DNA, biomarker, BMI}, journal = {Mutation research. Genetic toxicology and environmental mutagenesis}, doi = {10.1016/j.mrgentox.2022.503447}, volume = {1}, issn = {1383-5718}, title = {A pooled analysis of molecular epidemiological studies on modulation of DNA repair by host factors}, keyword = {DNA repair, comet assay, base excision repair, oxidatively damaged DNA, biomarker, BMI}, chapternumber = {503447} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati:





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font