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Pregled bibliografske jedinice broj: 1172344

Environmental Factors That Affect Parathyroid Hormone and Calcitonin Levels


Babić Leko, Mirjana; Pleić, Nikolina; Gunjača, Ivana; Zemunik, Tatijana
Environmental Factors That Affect Parathyroid Hormone and Calcitonin Levels // International Journal of Molecular Sciences, 23 (2021), 1; 10.3390/ijms23010044, 26 doi:10.3390/ijms23010044 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1172344 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Environmental Factors That Affect Parathyroid Hormone and Calcitonin Levels

Autori
Babić Leko, Mirjana ; Pleić, Nikolina ; Gunjača, Ivana ; Zemunik, Tatijana

Izvornik
International Journal of Molecular Sciences (1422-0067) 23 (2021), 1; 10.3390/ijms23010044, 26

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
PTH ; calcitonin ; calcium ; environmental factors ; lifestyle factors ; phosphate ; pollutants ; vitamin D

Sažetak
Calciotropic hormones, parathyroid hormone (PTH) and calcitonin are involved in the regulation of bone mineral metabolism and maintenance of calcium and phosphate homeostasis in the body. Therefore, an understanding of environmental and genetic factors influencing PTH and calcitonin levels is crucial. Genetic factors are estimated to account for 60% of variations in PTH levels, while the genetic background of interindividual calcitonin variations has not yet been studied. In this review, we analyzed the literature discussing the influence of environmental factors (lifestyle factors and pollutants) on PTH and calcitonin levels. Among lifestyle factors, smoking, body mass index (BMI), diet, alcohol, and exercise were analyzed ; among pollutants, heavy metals and chemicals were analyzed. Lifestyle factors that showed the clearest association with PTH levels were smoking, BMI, exercise, and micronutrients taken from the diet (vitamin D and calcium). Smoking, vitamin D, and calcium intake led to a decrease in PTH levels, while higher BMI and exercise led to an increase in PTH levels. In terms of pollutants, exposure to cadmium led to a decrease in PTH levels, while exposure to lead increased PTH levels. Several studies have investigated the effect of chemicals on PTH levels in humans. Compared to PTH studies, a smaller number of studies analyzed the influence of environmental factors on calcitonin levels, which gives great variability in results. Only a few studies have analyzed the influence of pollutants on calcitonin levels in humans. The lifestyle factor with the clearest relationship with calcitonin was smoking (smokers had increased calcitonin levels). Given the importance of PTH and calcitonin in maintaining calcium and phosphate homeostasis and bone mineral metabolism, additional studies on the influence of environmental factors that could affect PTH and calcitonin levels are crucial.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
HRZZ-IP-2019-04-2593 - Reguliranje funkcije štitne i doštitne žlijezde i homeostaze kalcija u krvi (THPTHCAREGULATION) (Zemunik, Tatijana, HRZZ - 2019-04) ( POIROT)

Ustanove:
Medicinski fakultet, Split

Poveznice na cjeloviti tekst rada:

doi www.mdpi.com

Citiraj ovu publikaciju:

Babić Leko, Mirjana; Pleić, Nikolina; Gunjača, Ivana; Zemunik, Tatijana
Environmental Factors That Affect Parathyroid Hormone and Calcitonin Levels // International Journal of Molecular Sciences, 23 (2021), 1; 10.3390/ijms23010044, 26 doi:10.3390/ijms23010044 (međunarodna recenzija, članak, znanstveni)
Babić Leko, M., Pleić, N., Gunjača, I. & Zemunik, T. (2021) Environmental Factors That Affect Parathyroid Hormone and Calcitonin Levels. International Journal of Molecular Sciences, 23 (1), 10.3390/ijms23010044, 26 doi:10.3390/ijms23010044.
@article{article, author = {Babi\'{c} Leko, Mirjana and Plei\'{c}, Nikolina and Gunja\v{c}a, Ivana and Zemunik, Tatijana}, year = {2021}, pages = {26}, DOI = {10.3390/ijms23010044}, chapter = {10.3390/ijms23010044}, keywords = {PTH, calcitonin, calcium, environmental factors, lifestyle factors, phosphate, pollutants, vitamin D}, journal = {International Journal of Molecular Sciences}, doi = {10.3390/ijms23010044}, volume = {23}, number = {1}, issn = {1422-0067}, title = {Environmental Factors That Affect Parathyroid Hormone and Calcitonin Levels}, keyword = {PTH, calcitonin, calcium, environmental factors, lifestyle factors, phosphate, pollutants, vitamin D}, chapternumber = {10.3390/ijms23010044} }
@article{article, author = {Babi\'{c} Leko, Mirjana and Plei\'{c}, Nikolina and Gunja\v{c}a, Ivana and Zemunik, Tatijana}, year = {2021}, pages = {26}, DOI = {10.3390/ijms23010044}, chapter = {10.3390/ijms23010044}, keywords = {PTH, calcitonin, calcium, environmental factors, lifestyle factors, phosphate, pollutants, vitamin D}, journal = {International Journal of Molecular Sciences}, doi = {10.3390/ijms23010044}, volume = {23}, number = {1}, issn = {1422-0067}, title = {Environmental Factors That Affect Parathyroid Hormone and Calcitonin Levels}, keyword = {PTH, calcitonin, calcium, environmental factors, lifestyle factors, phosphate, pollutants, vitamin D}, chapternumber = {10.3390/ijms23010044} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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