engleski

Study of 188 DAT-positive patients, part II: implications for transfusion treatment

Materials and methods: Described in Part I.Results:14% DAT-positive patients (DATs) at first admission were proved as not transfused/pregnant but 38% requested transfusion of which 76% urgently. Positive Ab screening in 85% DATs with urgent request revealed 15 polyspecific, five specific(three e, one C + e, one c) autoAbs and 34 alloAbs (nine with autoAbs). Anti-E, K, Cand c were found in 21, 11, 7 and 4% urgent DATs, respectively. 71% DATs requested blood during 2 years: 26% in one, 51% in two to nine and 23% in more than nine occasions. Transfusion was at least once cancelled in 10% and postponed for >4 h in35% DATs (in 17% >24 h), in 77 and 92% at first admission. 55% postponements >24 h were due to auto, 30% to allo and 15% to auto + alloAbs. Monoclonal patient typing could not be done due to prior transfusion in 17% and polyclonal without laborious procedures in another 54% DATs. In D-positive DATs prophylactic Rh-K-Jk- matched transfusions (PAM) would be often neg for E-K-Jkb (22%), E-K-Jka (18%), E-c-K-Jkbor E-K (15%). For each blood unit 6.7, 8.3, 25.0 and 1.9 donors should be screened, respectively. In D- negative DATs units would be negative for C-E-K- Jka (39%) andC-E-K-Jkb (28%), with 5.3 and 3.8 donors screened, respectively. Conclusions: Due to many urgent transfusions, positive Ab screening and cancelled/postponed requests, rational approach at least in our case seems to be: autoAbabsorption + identification + complete typing at first admission, and Rh-K- JkPAM + serum antibody identification at blood transfusion.

Study of 188 DAT-positive patients, part II: implications for transfusiontreatment

nije evidentirano