engleski

HPMC matrix tablets swelling properties as a prediction tool for gliclazide release behavior by texture analysis

The aim of this study was to monitor swelling process and gel growth by using texture analyzer and to investigate the kinetics of drug release from HPMC matrix tablets. The texture analyzer method for monitoring swelling process was proven to be sensitive to small differences in gel properties. Drug release mechanism is pH independent and was found to be a complex combination of diffusion, swelling and erosion. However, this study shows that the matrix swelling and gliclazide release is mainly achieved by diffusion process caused by the softening of the gel formed.

gliclazide ; HPMC matrix ; swelling ; texture analysis ; drug release

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