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Pregled bibliografske jedinice broj: 1171473

Subchronic exposure of individual and combined ochratoxin A and citrinin selectively affects the expression of rat renal organic cation transporters


Karaica, Dean; Micek, Vedran; Rašić, Dubravka; Peraica, Maja; Šegvić Klarić, Maja; Breljak, Davorka
Subchronic exposure of individual and combined ochratoxin A and citrinin selectively affects the expression of rat renal organic cation transporters // Mycotoxin research, 38 (2022), 1; 339-352 doi:10.1007/s12550-022-00450-6 (međunarodna recenzija, članak, ostalo)


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Naslov
Subchronic exposure of individual and combined ochratoxin A and citrinin selectively affects the expression of rat renal organic cation transporters

Autori
Karaica, Dean ; Micek, Vedran ; Rašić, Dubravka ; Peraica, Maja ; Šegvić Klarić, Maja ; Breljak, Davorka

Izvornik
Mycotoxin research (0178-7888) 38 (2022), 1; 339-352

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, ostalo

Ključne riječi
In vivo ; Kidney, Mycotoxin ; Nephrotoxicity ; Resveratrol ; Slc22 family

Sažetak
Ochratoxin A (OTA) and citrinin (CIT) are nephrotoxins found co-occurring in various human/animal food/feed and recog- nized as a health threat. However, most studies investigate individual effects and neglect their combined nephrotoxic effects in mammals. Previous studies have indicated that organic anion/cation transporters (OATs/OCTs) localized in renal proximal tubules mediate the transport of OTA and CIT. Still, little is known about the in vivo effects of individual/combined OTA and CIT on protein localization/expression of OCTs, physiologically/pharmacologically important renal transporters. Here, we used Western blot and immunofluorescence microscopy to study the effects of subchronic (21-day) exposure to individual/ combined OTA (0.125 and 0.250 mg kg−1 b.w.) and CIT (20 mg kg−1 b.w.) on protein localization/expression of organic cation transporters (rOct1/Slc22a1 and rOct2/Slc22a2) in kidneys of Wistar rats. Since the antioxidant resveratrol (RSV) has shown measurable protective effects against OTA- and CIT-related oxidative stress toxicity in vitro, we investigated the effects of an OTA + CIT + RSV combination on rOct1/2 localization/expression in the same model. Individual OTA induced a dose-dependent decrease of rOct1 but not rOct2 protein expression, whereas their localization pattern remained unchanged. Individual CIT did not affect the renal rOct1/2 protein localization/expression. Combined OTA + CIT exposure induced a significant decrease of rOct1 protein expression by an OTA250 dose, whereas oral co-administration of OTA + CIT + RSV resulted in a significant decrease of rOct1/2 protein expression. Thus, we revealed an OTA-related selective effect on the rOct1/2 protein expression and a non-specific adverse effect of RSV in the OTA + CIT + RSV combination on the renal organic cation transport system in rat.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Farmacija



POVEZANOST RADA


Projekti:
HRZZ-IP-2014-09-5982 - Štetni učinci pojedinačnih i kombiniranih mikotoksina Aspergillus vrsta (MycotoxA) (Šegvić Klarić, Maja, HRZZ - 2014-09) ( POIROT)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Institut za medicinska istraživanja i medicinu rada, Zagreb

Poveznice na cjeloviti tekst rada:

doi rdcu.be

Citiraj ovu publikaciju:

Karaica, Dean; Micek, Vedran; Rašić, Dubravka; Peraica, Maja; Šegvić Klarić, Maja; Breljak, Davorka
Subchronic exposure of individual and combined ochratoxin A and citrinin selectively affects the expression of rat renal organic cation transporters // Mycotoxin research, 38 (2022), 1; 339-352 doi:10.1007/s12550-022-00450-6 (međunarodna recenzija, članak, ostalo)
Karaica, D., Micek, V., Rašić, D., Peraica, M., Šegvić Klarić, M. & Breljak, D. (2022) Subchronic exposure of individual and combined ochratoxin A and citrinin selectively affects the expression of rat renal organic cation transporters. Mycotoxin research, 38 (1), 339-352 doi:10.1007/s12550-022-00450-6.
@article{article, author = {Karaica, Dean and Micek, Vedran and Ra\v{s}i\'{c}, Dubravka and Peraica, Maja and \v{S}egvi\'{c} Klari\'{c}, Maja and Breljak, Davorka}, year = {2022}, pages = {339-352}, DOI = {10.1007/s12550-022-00450-6}, keywords = {In vivo, Kidney, Mycotoxin, Nephrotoxicity, Resveratrol, Slc22 family}, journal = {Mycotoxin research}, doi = {10.1007/s12550-022-00450-6}, volume = {38}, number = {1}, issn = {0178-7888}, title = {Subchronic exposure of individual and combined ochratoxin A and citrinin selectively affects the expression of rat renal organic cation transporters}, keyword = {In vivo, Kidney, Mycotoxin, Nephrotoxicity, Resveratrol, Slc22 family} }
@article{article, author = {Karaica, Dean and Micek, Vedran and Ra\v{s}i\'{c}, Dubravka and Peraica, Maja and \v{S}egvi\'{c} Klari\'{c}, Maja and Breljak, Davorka}, year = {2022}, pages = {339-352}, DOI = {10.1007/s12550-022-00450-6}, keywords = {In vivo, Kidney, Mycotoxin, Nephrotoxicity, Resveratrol, Slc22 family}, journal = {Mycotoxin research}, doi = {10.1007/s12550-022-00450-6}, volume = {38}, number = {1}, issn = {0178-7888}, title = {Subchronic exposure of individual and combined ochratoxin A and citrinin selectively affects the expression of rat renal organic cation transporters}, keyword = {In vivo, Kidney, Mycotoxin, Nephrotoxicity, Resveratrol, Slc22 family} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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