Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 1171464

Evaluation of SARS-CoV-2 rapid diagnostic antigen test in COVID-19 suspected patients in Croatia


Mrdeža, Antonia; Rode, Fran; Cetinić Balent, Nataša; Kurolt, Ivan Christian; Bodulić, Kristian; Japirko, Ivana; Maretić, Ana; Đaković Rode, Oktavija
Evaluation of SARS-CoV-2 rapid diagnostic antigen test in COVID-19 suspected patients in Croatia // 31st European Congress of Clinical Microbiology & Infectious Diseases (ECCMID)
Online, 2021. 1199, 1 (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 1171464 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Evaluation of SARS-CoV-2 rapid diagnostic antigen test in COVID-19 suspected patients in Croatia

Autori
Mrdeža, Antonia ; Rode, Fran ; Cetinić Balent, Nataša ; Kurolt, Ivan Christian ; Bodulić, Kristian ; Japirko, Ivana ; Maretić, Ana ; Đaković Rode, Oktavija

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
31st European Congress of Clinical Microbiology & Infectious Diseases (ECCMID) / - , 2021

Skup
31st European Congress of Clinical Microbiology & Infectious Diseases (ECCMID)

Mjesto i datum
Online, 09-12.07.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
SARS-CoV-2 rapid antigen test ; COVID-19 patients ; diagnostic accuracy

Sažetak
Background The gold standard for COVID-19 diagnosis is reverse transcription-polymerase chain reaction (RT-PCR) test. The fast spreading of SARS-COV-2 contributed to the need for using tests with quicker results. Rapid antigen detection tests (Ag-RDT) differ in their specificity and sensitivity, which should be as close as possible to the gold standard. Methods During November and December 2020, nasopharyngeal swabs (NPS) were obtained from COVID-19 suspected patients at the University Hospital for Infectious Diseases, Zagreb, Croatia, and tested immediately on-site with Ag-RDT for SARS-CoV-2 (SARS-CoV-2 Rapid Antigen Test Roche/SD Biosensor, Germany/Korea) following manufacturer's instructions. In case of negative Ag-RDT, a new NPS was tested for viral RNA with RT-PCR Roche cobas® SARS-CoV-2 Test (Mannheim, Germany). Diagnostic accuracy of Ag-RDT was determined in comparison to the RT-PCR. The results were evaluated according to the time of symptom onset, patient age and gender. Results Out of 1317 patients (mean age 50.47 years (SD 21.15) ; males 52.01%), 788 (66.94%) were confirmed for COVID-19. Within the first seven days and from day eight after symptom onset, SARS- CoV-2 Ag-RDT was positive in 555 (49.73%) and 96 (47.76%) patients, respectively. False-negative Ag-RDT and RT-PCR positive findings were found in 84 (7.53%) patients within the first seven days, and in 55 (27.36%) from day eight after symptom onset. Overall sensitivity and specificity of Ag- RDT was 82.36% (95%CI 80.42-85.01) and 99.49% (95%CI 98.32- 100%), respectively, with Cohen’s Kappa 0.75 (95% CI 0.71-0.79). Test sensitivity for patients with NPS collected within the first seven days of illness and from day eight after symptom onset was 86.81% (95% CI 84.05-89.00) and 63.58% (95%CI 55.54-71.14), with Cohen’s Kappa 0.82 (95% CI 0.79-0.86) and 0.39 (95% CI 0.28- 0.49), respectively. Tests done eight or more days after symptom onset were found to have a significantly higher odds of falsenegative results (OR 3.76 ; 95%CI 2.46-5.74, p=0.0). Conclusions SARS- COV-2 Ag-RDT showed good agreement with RT-PCR, especially in the first week after symptom onset. The accuracy of Ag-RDT depends on the collection sample time after symptom onset. In case of Ag-RDT negative result, RT-PCR test is obligatory. Furthermore, in the late stage of disease, serology is recommended.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
Stomatološki fakultet, Zagreb,
Klinika za infektivne bolesti "Dr Fran Mihaljević"


Citiraj ovu publikaciju:

Mrdeža, Antonia; Rode, Fran; Cetinić Balent, Nataša; Kurolt, Ivan Christian; Bodulić, Kristian; Japirko, Ivana; Maretić, Ana; Đaković Rode, Oktavija
Evaluation of SARS-CoV-2 rapid diagnostic antigen test in COVID-19 suspected patients in Croatia // 31st European Congress of Clinical Microbiology & Infectious Diseases (ECCMID)
Online, 2021. 1199, 1 (poster, međunarodna recenzija, sažetak, znanstveni)
Mrdeža, A., Rode, F., Cetinić Balent, N., Kurolt, I., Bodulić, K., Japirko, I., Maretić, A. & Đaković Rode, O. (2021) Evaluation of SARS-CoV-2 rapid diagnostic antigen test in COVID-19 suspected patients in Croatia. U: 31st European Congress of Clinical Microbiology & Infectious Diseases (ECCMID).
@article{article, author = {Mrde\v{z}a, Antonia and Rode, Fran and Cetini\'{c} Balent, Nata\v{s}a and Kurolt, Ivan Christian and Boduli\'{c}, Kristian and Japirko, Ivana and Mareti\'{c}, Ana and \DJakovi\'{c} Rode, Oktavija}, year = {2021}, pages = {1}, chapter = {1199}, keywords = {SARS-CoV-2 rapid antigen test, COVID-19 patients, diagnostic accuracy}, title = {Evaluation of SARS-CoV-2 rapid diagnostic antigen test in COVID-19 suspected patients in Croatia}, keyword = {SARS-CoV-2 rapid antigen test, COVID-19 patients, diagnostic accuracy}, publisherplace = {Online}, chapternumber = {1199} }
@article{article, author = {Mrde\v{z}a, Antonia and Rode, Fran and Cetini\'{c} Balent, Nata\v{s}a and Kurolt, Ivan Christian and Boduli\'{c}, Kristian and Japirko, Ivana and Mareti\'{c}, Ana and \DJakovi\'{c} Rode, Oktavija}, year = {2021}, pages = {1}, chapter = {1199}, keywords = {SARS-CoV-2 rapid antigen test, COVID-19 patients, diagnostic accuracy}, title = {Evaluation of SARS-CoV-2 rapid diagnostic antigen test in COVID-19 suspected patients in Croatia}, keyword = {SARS-CoV-2 rapid antigen test, COVID-19 patients, diagnostic accuracy}, publisherplace = {Online}, chapternumber = {1199} }




Contrast
Increase Font
Decrease Font
Dyslexic Font