Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 1171252

Aspergilli in damp dwellings - how diverse and dangerous are they?


Šegvić Klarić, Maja; Jakšić, Daniela; Kocsube, Sandor; Kopjar, Nevenka; Kifer, Domagoj; Rašić, Dubravka; Sulyok, Michael; Šarkanj, Bojan; Peraica, Maja
Aspergilli in damp dwellings - how diverse and dangerous are they? // Arhiv za higijenu rada i toksikologiju, Supplement 1 / Lyons, Daniel Mark ; Brčić Karačonji, Irena ; Kopjar, Nevenka (ur.).
Zagreb: Hrvatsko toksikološko društvo, 2021. str. 19-19 (pozvano predavanje, domaća recenzija, sažetak, znanstveni)


CROSBI ID: 1171252 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Aspergilli in damp dwellings - how diverse and dangerous are they?

Autori
Šegvić Klarić, Maja ; Jakšić, Daniela ; Kocsube, Sandor ; Kopjar, Nevenka ; Kifer, Domagoj ; Rašić, Dubravka ; Sulyok, Michael ; Šarkanj, Bojan ; Peraica, Maja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Arhiv za higijenu rada i toksikologiju, Supplement 1 / Lyons, Daniel Mark ; Brčić Karačonji, Irena ; Kopjar, Nevenka - Zagreb : Hrvatsko toksikološko društvo, 2021, 19-19

Skup
VI. Croatian Congress of Toxicology with International Participation

Mjesto i datum
Rabac, Hrvatska, 4.-7.10.2021

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
5-methoxysterigmatocystin ; Aspergillus series Versicolores ; fungal metabolites ; genotoxicity ; sterigmatocystin

Sažetak
Aspergilli section Nidulantes series Versicolores, producers of the mycotoxin sterigmatocystin (STC), dominated the fungi isolated from air and dust in flood-affected homes (Gunja) and control houses (Gornji Stupnik) in Croatia. The majority of isolates were able to produce STC and some isolates also produced its derivate 5- methoxysterigmatocystin (5-MET-STC). How can this affect human health? Here we present: a) Aspergilli series Versicolores species diversity in air and dust (calmodulin sequence-based methods) ; b) occurrence of STC and metabolites from the STC biosynthesis pathway in dust (LC- MS/MS) ; and c) immunomodulatory and genotoxic effects of STC and 5-MET-STC in lungs of male Wistar rats upon intratracheal instillation in concentrations found in dust. Most of the Versicolores isolates were from Gunja (91/125). Most isolates belonging to A. jensenii, A. creber, A. puulaauensis, A. tennesseensis, A. venenatus produced both STC and 5-MET-STC. A. amoenus, A. fructus, A. griseoaurantiacus, A. pepii and A. protuberus produced STC but not 5-MET-STC, while A. sydowii did not produce any of these two toxins. Among the 75 fungal compounds detected in dust, metabolites from the STC pathway including STC, 5-MET-STC, veriscolorin C, averufin and averantin were among the most abundant metabolites, which prevailed in repaired houses in Gunja. The highest concentrations of STC (0.59 µg/g) and 5-MET-STC (7.70 µg/g) in dust were detected in Gunja. In rat lungs, the immunomodulatory effects of STC (0.4 µg/mL) and 5- MET-STC (5 µg/mL) were insignificant. The levels of DNA damage were similar although STC was applied at a 10-fold lower dose. The results of combined treatment suggested possible antagonistic interactions. This work was fully supported by the Croatian Science Foundation under the project MycotoxA (IP-09-2014-5982).

Izvorni jezik
Engleski

Znanstvena područja
Interdisciplinarne prirodne znanosti, Temeljne medicinske znanosti, Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA


Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Sveučilište Sjever, Koprivnica

Poveznice na cjeloviti tekst rada:

hrcak.srce.hr

Citiraj ovu publikaciju:

Šegvić Klarić, Maja; Jakšić, Daniela; Kocsube, Sandor; Kopjar, Nevenka; Kifer, Domagoj; Rašić, Dubravka; Sulyok, Michael; Šarkanj, Bojan; Peraica, Maja
Aspergilli in damp dwellings - how diverse and dangerous are they? // Arhiv za higijenu rada i toksikologiju, Supplement 1 / Lyons, Daniel Mark ; Brčić Karačonji, Irena ; Kopjar, Nevenka (ur.).
Zagreb: Hrvatsko toksikološko društvo, 2021. str. 19-19 (pozvano predavanje, domaća recenzija, sažetak, znanstveni)
Šegvić Klarić, M., Jakšić, D., Kocsube, S., Kopjar, N., Kifer, D., Rašić, D., Sulyok, M., Šarkanj, B. & Peraica, M. (2021) Aspergilli in damp dwellings - how diverse and dangerous are they?. U: Lyons, D., Brčić Karačonji, I. & Kopjar, N. (ur.)Arhiv za higijenu rada i toksikologiju, Supplement 1.
@article{article, author = {\v{S}egvi\'{c} Klari\'{c}, Maja and Jak\v{s}i\'{c}, Daniela and Kocsube, Sandor and Kopjar, Nevenka and Kifer, Domagoj and Ra\v{s}i\'{c}, Dubravka and Sulyok, Michael and \v{S}arkanj, Bojan and Peraica, Maja}, year = {2021}, pages = {19-19}, keywords = {5-methoxysterigmatocystin, Aspergillus series Versicolores, fungal metabolites, genotoxicity, sterigmatocystin}, title = {Aspergilli in damp dwellings - how diverse and dangerous are they?}, keyword = {5-methoxysterigmatocystin, Aspergillus series Versicolores, fungal metabolites, genotoxicity, sterigmatocystin}, publisher = {Hrvatsko toksikolo\v{s}ko dru\v{s}tvo}, publisherplace = {Rabac, Hrvatska} }
@article{article, author = {\v{S}egvi\'{c} Klari\'{c}, Maja and Jak\v{s}i\'{c}, Daniela and Kocsube, Sandor and Kopjar, Nevenka and Kifer, Domagoj and Ra\v{s}i\'{c}, Dubravka and Sulyok, Michael and \v{S}arkanj, Bojan and Peraica, Maja}, year = {2021}, pages = {19-19}, keywords = {5-methoxysterigmatocystin, Aspergillus series Versicolores, fungal metabolites, genotoxicity, sterigmatocystin}, title = {Aspergilli in damp dwellings - how diverse and dangerous are they?}, keyword = {5-methoxysterigmatocystin, Aspergillus series Versicolores, fungal metabolites, genotoxicity, sterigmatocystin}, publisher = {Hrvatsko toksikolo\v{s}ko dru\v{s}tvo}, publisherplace = {Rabac, Hrvatska} }




Contrast
Increase Font
Decrease Font
Dyslexic Font