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Pregled bibliografske jedinice broj: 1171246

Effects of two types of anaesthesia on oxidative stress in plasma in patients with hydronephrosis


Rašić, Dubravka; Alavuk Kundović, Sandra; Kifer, Domagoj; Črnjar, Ksenija; Popović, Ljiljana; Peraica Maja
Effects of two types of anaesthesia on oxidative stress in plasma in patients with hydronephrosis // Arhiv za higijenu rada i toksikologiju 72 (Suppl.1) / Lyons, Daniel Mark ; Brčić Karačonji, Irena ; Kopjar, Nevenka (ur.).
Zagreb: Hrvatsko toksikološko društvo, 2021. str. 40-40 (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 1171246 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Effects of two types of anaesthesia on oxidative stress in plasma in patients with hydronephrosis

Autori
Rašić, Dubravka ; Alavuk Kundović, Sandra ; Kifer, Domagoj ; Črnjar, Ksenija ; Popović, Ljiljana ; Peraica Maja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Arhiv za higijenu rada i toksikologiju 72 (Suppl.1) / Lyons, Daniel Mark ; Brčić Karačonji, Irena ; Kopjar, Nevenka - Zagreb : Hrvatsko toksikološko društvo, 2021, 40-40

Skup
6. hrvatski toksikološki kongres s međunarodnim sudjelovanjem CROTOX 2021

Mjesto i datum
Rabac, Hrvatska, 04-07.10.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
balanced anaesthesia ; glutathione ; malondialdehyde ; surgery ; target-controlled infusion

Sažetak
Human studies on oxidative stress induced by general anaesthesia are rather scarce. It is important to study effects of anaesthetics on oxidative stress, particularly in surgical procedures with high ROS production, because their effect may be pivotal for the outcome of the surgery. In the presented study, patients with hydronephrosis underwent balanced anaesthesia or Total Intravenous Anaesthesia (TIVA) with target- controlled infusion (TCI) during surgery. Blood samples from patients (N=32) were taken before induction of anaesthesia, 30 minutes and 24 hours after beginning of the surgery. Measured parameters of oxidative stress were compared between two types of anaesthesia. Malondialdehyde (MDA) was measured using HPLC with fluorescence detector. Glutathione (GSH), reactive oxygen species (ROS), total antioxidant capacity (TOC) and protein carbonyl concentration were measured spectrophotometrically. Activity of superoxide dismutase (SOD) was measured spectrophotometrically using commercial kits. Observed data were analysed by mixed modelling with oxidative stress parameter as a dependent variable and sampling time nested within an anaesthetic group as fixed effects, and subject id as a random effect. Post-hoc were performed and the false discovery rate was controlled by the Benjamini-Hochberg method. SOD activity was significantly higher in patients that underwent balanced anaesthesia than anaesthesia with TIVA/TCI 30 minutes after beginning of the surgery. There was no statistically significant difference in other measured parameters between balanced and TIVA/TCI type of anaesthesia. Results of the majority of the measured parameters of oxidative stress were significantly different 30 minutes or 24 hours after the surgery from those measured before the anaesthesia (balanced and TIVA/ TCI). Results from this study contribute to general knowledge about oxidative stress caused by anaesthesia as an important factor in causing higher rates of postoperative complications and delayed recovery after surgery.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Klinika za dječje bolesti

Profili:

Avatar Url Domagoj Kifer (autor)

Avatar Url Maja Peraica (autor)

Avatar Url Ljiljana Popović (autor)

Avatar Url Dubravka Rašić (autor)

Poveznice na cjeloviti tekst rada:

hrcak.srce.hr

Citiraj ovu publikaciju:

Rašić, Dubravka; Alavuk Kundović, Sandra; Kifer, Domagoj; Črnjar, Ksenija; Popović, Ljiljana; Peraica Maja
Effects of two types of anaesthesia on oxidative stress in plasma in patients with hydronephrosis // Arhiv za higijenu rada i toksikologiju 72 (Suppl.1) / Lyons, Daniel Mark ; Brčić Karačonji, Irena ; Kopjar, Nevenka (ur.).
Zagreb: Hrvatsko toksikološko društvo, 2021. str. 40-40 (poster, međunarodna recenzija, sažetak, znanstveni)
Rašić, D., Alavuk Kundović, S., Kifer, D., Črnjar, K., Popović, L. & Peraica Maja (2021) Effects of two types of anaesthesia on oxidative stress in plasma in patients with hydronephrosis. U: Lyons, D., Brčić Karačonji, I. & Kopjar, N. (ur.)Arhiv za higijenu rada i toksikologiju 72 (Suppl.1).
@article{article, author = {Ra\v{s}i\'{c}, Dubravka and Alavuk Kundovi\'{c}, Sandra and Kifer, Domagoj and \v{C}rnjar, Ksenija and Popovi\'{c}, Ljiljana}, year = {2021}, pages = {40-40}, keywords = {balanced anaesthesia, glutathione, malondialdehyde, surgery, target-controlled infusion}, title = {Effects of two types of anaesthesia on oxidative stress in plasma in patients with hydronephrosis}, keyword = {balanced anaesthesia, glutathione, malondialdehyde, surgery, target-controlled infusion}, publisher = {Hrvatsko toksikolo\v{s}ko dru\v{s}tvo}, publisherplace = {Rabac, Hrvatska} }
@article{article, author = {Ra\v{s}i\'{c}, Dubravka and Alavuk Kundovi\'{c}, Sandra and Kifer, Domagoj and \v{C}rnjar, Ksenija and Popovi\'{c}, Ljiljana}, year = {2021}, pages = {40-40}, keywords = {balanced anaesthesia, glutathione, malondialdehyde, surgery, target-controlled infusion}, title = {Effects of two types of anaesthesia on oxidative stress in plasma in patients with hydronephrosis}, keyword = {balanced anaesthesia, glutathione, malondialdehyde, surgery, target-controlled infusion}, publisher = {Hrvatsko toksikolo\v{s}ko dru\v{s}tvo}, publisherplace = {Rabac, Hrvatska} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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