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Pregled bibliografske jedinice broj: 1171149

BMP3 Affects Cortical and Trabecular Long Bone Development in Mice


Banovac, Ivan; Grgurević, Lovorka; Rumenović, Viktorija; Vukičević, Slobodan; Erjavec, Igor
BMP3 Affects Cortical and Trabecular Long Bone Development in Mice // International journal of molecular sciences, 23 (2022), 2; 785, 16 doi:10.3390/ijms23020785 (međunarodna recenzija, članak, znanstveni)


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Naslov
BMP3 Affects Cortical and Trabecular Long Bone Development in Mice

Autori
Banovac, Ivan ; Grgurević, Lovorka ; Rumenović, Viktorija ; Vukičević, Slobodan ; Erjavec, Igor

Izvornik
International journal of molecular sciences (1422-0067) 23 (2022), 2; 785, 16

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Bmp3 ; micro-CT ; long bone ; cortical bone ; growth plate

Sažetak
Bone morphogenetic proteins (BMPs) have a major role in tissue development. BMP3 is synthesized in osteocytes and mature osteoblasts and has an antagonistic effect on other BMPs in bone tissue. The main aim of this study was to fully characterize cortical bone and trabecular bone of long bones in both male and female Bmp3−/− mice. To investigate the effect of Bmp3 from birth to maturity, we compared Bmp3−/− mice with wild-type littermates at the following stages of postnatal development: 1 day (P0), 2 weeks (P14), 8 weeks and 16 weeks of age. Bmp3 deletion was confirmed using X-gal staining in P0 animals. Cartilage and bone tissue were examined in P14 animals using Alcian Blue/Alizarin Red staining. Detailed long bone analysis was performed in 8-week-old and 16- week-old animals using micro-CT. The Bmp3 reporter signal was localized in bone tissue, hair follicles, and lungs. Bone mineralization at 2 weeks of age was increased in long bones of Bmp3−/ − mice. Bmp3 deletion was shown to affect the skeleton until adulthood, where increased cortical and trabecular bone parameters were found in young and adult mice of both sexes, while delayed mineralization of the epiphyseal growth plate was found in adult Bmp3−/− mice.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
EK-EFRR-KK.01.1.1.01.0008 - Znanstveni centar izvrsnosti za reproduktivnu i regenerativnu medicinu – istraživanja novih platormi i potencijala (CERRM) (Volarević, Siniša; Vukičević, Slobodan; Ježek, Davor, EK - KK.01.1.1.01) ( POIROT)
HRZZ-IP-2020-02-5960 - Utjecaj koštanog morfogenetskog proteina 3 (BMP3) na regeneraciju kosti (BON3gen) (Erjavec, Igor, HRZZ - IP-2020-02) ( POIROT)

Ustanove:
Medicinski fakultet, Zagreb

Poveznice na cjeloviti tekst rada:

Pristup cjelovitom tekstu rada doi www.mdpi.com

Citiraj ovu publikaciju:

Banovac, Ivan; Grgurević, Lovorka; Rumenović, Viktorija; Vukičević, Slobodan; Erjavec, Igor
BMP3 Affects Cortical and Trabecular Long Bone Development in Mice // International journal of molecular sciences, 23 (2022), 2; 785, 16 doi:10.3390/ijms23020785 (međunarodna recenzija, članak, znanstveni)
Banovac, I., Grgurević, L., Rumenović, V., Vukičević, S. & Erjavec, I. (2022) BMP3 Affects Cortical and Trabecular Long Bone Development in Mice. International journal of molecular sciences, 23 (2), 785, 16 doi:10.3390/ijms23020785.
@article{article, author = {Banovac, Ivan and Grgurevi\'{c}, Lovorka and Rumenovi\'{c}, Viktorija and Vuki\v{c}evi\'{c}, Slobodan and Erjavec, Igor}, year = {2022}, pages = {16}, DOI = {10.3390/ijms23020785}, chapter = {785}, keywords = {Bmp3, micro-CT, long bone, cortical bone, growth plate}, journal = {International journal of molecular sciences}, doi = {10.3390/ijms23020785}, volume = {23}, number = {2}, issn = {1422-0067}, title = {BMP3 Affects Cortical and Trabecular Long Bone Development in Mice}, keyword = {Bmp3, micro-CT, long bone, cortical bone, growth plate}, chapternumber = {785} }
@article{article, author = {Banovac, Ivan and Grgurevi\'{c}, Lovorka and Rumenovi\'{c}, Viktorija and Vuki\v{c}evi\'{c}, Slobodan and Erjavec, Igor}, year = {2022}, pages = {16}, DOI = {10.3390/ijms23020785}, chapter = {785}, keywords = {Bmp3, micro-CT, long bone, cortical bone, growth plate}, journal = {International journal of molecular sciences}, doi = {10.3390/ijms23020785}, volume = {23}, number = {2}, issn = {1422-0067}, title = {BMP3 Affects Cortical and Trabecular Long Bone Development in Mice}, keyword = {Bmp3, micro-CT, long bone, cortical bone, growth plate}, chapternumber = {785} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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