Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

Ferrocene conjugates linked by 1,2,3-triazole and their Zn(II) and Cu(II) complexes: Synthesis, characterization and biological activity (CROSBI ID 303827)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Jakopec, Silvio ; Pantalon Juraj, Natalija ; Brozović, Anamaria ; Jadreško, Dijana ; Perić, Berislav ; Kirin, Srećko I. ; Raić-Malić, Silvana Ferrocene conjugates linked by 1,2,3-triazole and their Zn(II) and Cu(II) complexes: Synthesis, characterization and biological activity // Applied organometallic chemistry, 36 (2022), 4; e6575, 22. doi: 10.1002/aoc.6575

Podaci o odgovornosti

Jakopec, Silvio ; Pantalon Juraj, Natalija ; Brozović, Anamaria ; Jadreško, Dijana ; Perić, Berislav ; Kirin, Srećko I. ; Raić-Malić, Silvana

engleski

Ferrocene conjugates linked by 1,2,3-triazole and their Zn(II) and Cu(II) complexes: Synthesis, characterization and biological activity

Ferrocene derivatives with mono- (8a–c) and bis- 1, 2, 3-triazolyl (9 and 10a–13c) chelating groups were synthesized by regioselective copper(I)- catalysed 1, 3-dipolar cycloaddition of terminal alkynes with ferrocene azides. Metal complexes of the ligands were prepared with Cu(II) and Zn(II) salts. Crystal structures of ligands 9 and 11a were determined, as well as the structures of complexes [Cu(8a)2] (CF3SO3)2 (8aCu) and [Cu(8c)2(CH3OH)2](BF4)2 (8cCu). In addition to NMR and UV–Vis spectroscopy, the metal complexes were characterized by cyclic voltammetry. The cytotoxic effect of ferrocene conjugates and their Zn(II) and Cu(II) complexes was explored, and cell cycle analysis was performed. The complex [Cu(8c)2](CF3SO3)2 showed the most prominent and selective cytotoxicity on cervical carcinoma (HeLa), ovarian cancer (MES-OV), non-small cell lung cancer (A549) and breast carcinoma (MDA-MB- 231) cells. This complex increased cell population in the S and G2/M phase of the cell cycle, which was accompanied by an increase of the cells present in the sub-G0/G1 fraction.

1, 2, 3-triazole ; cyclic voltammetry ; cytotoxicity ; ferrocene ; transition metal complex

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

36 (4)

2022.

e6575

22

objavljeno

0268-2605

1099-0739

10.1002/aoc.6575

Povezanost rada

Kemija

Poveznice
Indeksiranost