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izvor podataka: crosbi

Randomized Clinical Trial investigating Self- Assembling Peptide P11-4 for Treatment of Early Occlusal Caries (CROSBI ID 303814)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Doberdoli, Dafina ; Bommer, Claudine ; Begzati, Agim ; Haliti, Fehim ; Heinzel-Gutenbrunner, Monika ; Jurić, Hrvoje Randomized Clinical Trial investigating Self- Assembling Peptide P11-4 for Treatment of Early Occlusal Caries // Scientific reports, 10 (2020), 1; 4195, 8. doi: 10.1038/s41598-020-60815-8

Podaci o odgovornosti

Doberdoli, Dafina ; Bommer, Claudine ; Begzati, Agim ; Haliti, Fehim ; Heinzel-Gutenbrunner, Monika ; Jurić, Hrvoje

engleski

Randomized Clinical Trial investigating Self- Assembling Peptide P11-4 for Treatment of Early Occlusal Caries

Non-invasive caries treatment is a major focus in modern dentistry. The present study was designed to evaluate the effectiveness of monomeric self- assembling peptide P11-4 (SAP P11-4) in combination with fluoride varnish or polymeric self-assembling peptide matrix (SAPM) in treatment of non-cavitated occlusal caries. Ninety children and adolescents were included in this randomized, gold-standard-controlled clinical trial. Test Group 1 received SAP P11-4 and twice fluoride varnish at baseline and Day 180, Test Group 2 received SAP P11-4 on baseline and twice weekly SAPM (home-application), and Control Group received fluoride varnish on baseline and Day 180. Caries progression was measured by laser fluorescence, Nyvad Caries Activity, ICDAS-II- codes, and investigator assessments. Laser fluorescence changes demonstrated superior results for Test Group 1 and 2, as values decreased compared to an increase for the Control Group (p < 0.0005). ICDAS-II codes at Day 360 showed partial regression for Test Group 1 (6.7%) and Test Group 2 (20.0%) and partial progression for Control Group (23.3%) (p < 0.01). Nyvad Caries Activity yielded superior caries inactivation for Test Groups, compared to Control Group (p = 0.002). This trial showed that SAP P11-4, applied either in combination with fluoride varnish or twice weekly SAPM, was a superior treatment for early caries compared to fluoride varnish alone.

early occlusal caries ; fluorides ; self-assembling peptides

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Podaci o izdanju

10 (1)

2020.

4195

8

objavljeno

2045-2322

10.1038/s41598-020-60815-8

Povezanost rada

Dentalna medicina

Poveznice
Indeksiranost