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Chal-lenges of blood compatibilitiy testing and blood transfusion in patients treated with anti- CD38 monoclonal antibody

Both procedures used in our laboratory, RBC treatment with 0.2 M dithiothreitol-treated RBCs and neutralization test using DaraEx reagent, have not been shown to be sufficiently reliable in resolving the interference with the routine blood compatibility testing caused by the anti-CD38 monoclonal antibody. Therefore, for blood transfusion of these patients it is necessary to provide antigenmatched RBC units. Good collaboration between the ward and the transfusion service, with protocols in place for blood compatibility testing and blood transfusion, remains a precondition for timely and safe blood transfusion for this group of patients.

Chal-lenges, blood compatibilitiy testing , blood transfusion, anti-CD38 monoclonal antibody

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