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Vitamin D receptor polymorphism and susceptibility to type 1 diabetes in the Dalmatian population (CROSBI ID 100380)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Škrabić, Veselin ; Zemunik, Tatijana ; Šitum, Marjan ; Terzić, Janoš Vitamin D receptor polymorphism and susceptibility to type 1 diabetes in the Dalmatian population // Diabetes research and clinical practice, 59 (2003), 1; 31-35-x

Podaci o odgovornosti

Škrabić, Veselin ; Zemunik, Tatijana ; Šitum, Marjan ; Terzić, Janoš

engleski

Vitamin D receptor polymorphism and susceptibility to type 1 diabetes in the Dalmatian population

Several studies have found a relationship between polymorphisms of the vitamin D receptor gene (VDR) and development of type 1 diabetes (T1DM). The meaning of this observation remains unclear and its relevance must be checked in different population samples. To examine the association of VDR polymorphisms and susceptibility to T1DM in the Dalmatian population of South Croatia we studied 134 individuals with type 1 diabetes and 132 control subjects. VDR genotyping was performed using PCR and BsmI, ApaI and TaqI restriction enzymes. Data were analysed using the X2 test. The genotype combination which conferred strongest susceptibility to T1DM was BBAAtt (p=0.002). Interestingly, the BAt haplotype was found to be a risk factor in a German population, the only European population tested thus far. Our results indicate that VDR polymorphisms are associated with increased risk of T1DM in the Dalmatian population of South Croatia and warrant further studies.

vitamin D receptor; genotype; type 1 diabetes; genetic susceptibility; Dalmatia

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Podaci o izdanju

59 (1)

2003.

31-35-x

objavljeno

0168-8227

Povezanost rada

Farmacija

Indeksiranost