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Pregled bibliografske jedinice broj: 1169561

Divergent Effect of Central Incretin Receptors Inhibition in a Rat Model of Sporadic Alzheimer’s Disease


Osmanovic Barilar, Jelena; Knezovic, Ana; Homolak, Jan; Babic Perhoc, Ana; Salkovic-Petrisic, Melita
Divergent Effect of Central Incretin Receptors Inhibition in a Rat Model of Sporadic Alzheimer’s Disease // International Journal of Molecular Sciences, 23 (2022), 1; 548, 16 doi:10.3390/ijms23010548 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1169561 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Divergent Effect of Central Incretin Receptors Inhibition in a Rat Model of Sporadic Alzheimer’s Disease

Autori
Osmanovic Barilar, Jelena ; Knezovic, Ana ; Homolak, Jan ; Babic Perhoc, Ana ; Salkovic-Petrisic, Melita

Izvornik
International Journal of Molecular Sciences (1422-0067) 23 (2022), 1; 548, 16

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
glucagon-like peptide-1 ; gastric inhibitory polypeptide ; hippocampus ; hypothalamus ; Alzheimer’s disease

Sažetak
The incretin system is an emerging new field that might provide valuable contributions to the research of both the pathophysiology and therapeutic strategies in the treatment of diabetes, obesity, and neurodegenerative disorders. This study aimed to explore the roles of central glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP) on cell metabolism and energy in the brain, as well as on the levels of these incretins, insulin, and glucose via inhibition of the central incretin receptors following intracerebroventricular administration of the respective antagonists in healthy rats and a streptozotocin-induced rat model of sporadic Alzheimer’s disease (sAD). Chemical ablation of the central GIP receptor (GIPR) or GLP-1 receptor (GLP-1R) in healthy and diseased animals indicated a region-dependent role of incretins in brain cell energy and metabolism and central incretin-dependent modulation of peripheral hormone secretion, markedly after GIPR inhibition, as well as a dysregulation of the GLP- 1 system in experimental sAD.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
IP-2018-01-8938 - Mehanizmi nutrijentom posredovanih učinaka endogenog glukagonu sličnog peptida-1 na kognitivne i metaboličke poremećaje u eksperimentalnim modelima neurodegenerativnih bolesti (NutrientGLP-1) (Šalković-Petrišić, Melita, HRZZ - 2018-01) ( POIROT)
EK-EFRR-KK.01.1.1.01.0007 - Eksperimentalna i klinička istraživanja hipoksijsko-ishemijskog oštećenja mozga u perinatalnoj i odrasloj dobi (Kostović, Ivica, EK - KK.01.1.1.01) ( POIROT)

Ustanove:
Medicinski fakultet, Zagreb

Poveznice na cjeloviti tekst rada:

Pristup cjelovitom tekstu rada doi www.mdpi.com

Citiraj ovu publikaciju:

Osmanovic Barilar, Jelena; Knezovic, Ana; Homolak, Jan; Babic Perhoc, Ana; Salkovic-Petrisic, Melita
Divergent Effect of Central Incretin Receptors Inhibition in a Rat Model of Sporadic Alzheimer’s Disease // International Journal of Molecular Sciences, 23 (2022), 1; 548, 16 doi:10.3390/ijms23010548 (međunarodna recenzija, članak, znanstveni)
Osmanovic Barilar, J., Knezovic, A., Homolak, J., Babic Perhoc, A. & Salkovic-Petrisic, M. (2022) Divergent Effect of Central Incretin Receptors Inhibition in a Rat Model of Sporadic Alzheimer’s Disease. International Journal of Molecular Sciences, 23 (1), 548, 16 doi:10.3390/ijms23010548.
@article{article, author = {Osmanovic Barilar, Jelena and Knezovic, Ana and Homolak, Jan and Babic Perhoc, Ana and Salkovic-Petrisic, Melita}, year = {2022}, pages = {16}, DOI = {10.3390/ijms23010548}, chapter = {548}, keywords = {glucagon-like peptide-1, gastric inhibitory polypeptide, hippocampus, hypothalamus, Alzheimer’s disease}, journal = {International Journal of Molecular Sciences}, doi = {10.3390/ijms23010548}, volume = {23}, number = {1}, issn = {1422-0067}, title = {Divergent Effect of Central Incretin Receptors Inhibition in a Rat Model of Sporadic Alzheimer’s Disease}, keyword = {glucagon-like peptide-1, gastric inhibitory polypeptide, hippocampus, hypothalamus, Alzheimer’s disease}, chapternumber = {548} }
@article{article, author = {Osmanovic Barilar, Jelena and Knezovic, Ana and Homolak, Jan and Babic Perhoc, Ana and Salkovic-Petrisic, Melita}, year = {2022}, pages = {16}, DOI = {10.3390/ijms23010548}, chapter = {548}, keywords = {glucagon-like peptide-1, gastric inhibitory polypeptide, hippocampus, hypothalamus, Alzheimer’s disease}, journal = {International Journal of Molecular Sciences}, doi = {10.3390/ijms23010548}, volume = {23}, number = {1}, issn = {1422-0067}, title = {Divergent Effect of Central Incretin Receptors Inhibition in a Rat Model of Sporadic Alzheimer’s Disease}, keyword = {glucagon-like peptide-1, gastric inhibitory polypeptide, hippocampus, hypothalamus, Alzheimer’s disease}, chapternumber = {548} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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