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Pregled bibliografske jedinice broj: 116905

Synthesis and antitumor evaluation of some new substituted amidino-benzimidazolyl-furyl-phenyl-acrylates and naphtho[2, 1-b]furan-carboxylates


Hranjec, Marijana; Grdiša, Mira; Pavelić, Krešimir; Boykin, David W.; Karminski-Zamola, Grace
Synthesis and antitumor evaluation of some new substituted amidino-benzimidazolyl-furyl-phenyl-acrylates and naphtho[2, 1-b]furan-carboxylates // Farmaco, 58 (2003), 12; 1319-1324 (međunarodna recenzija, članak, znanstveni)


Naslov
Synthesis and antitumor evaluation of some new substituted amidino-benzimidazolyl-furyl-phenyl-acrylates and naphtho[2, 1-b]furan-carboxylates

Autori
Hranjec, Marijana ; Grdiša, Mira ; Pavelić, Krešimir ; Boykin, David W. ; Karminski-Zamola, Grace

Izvornik
Farmaco (0014-827X) 58 (2003), 12; 1319-1324

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Synthesis; antitumor activiti; substituted amidino-benzimidazolyl-furyl-phenyl-acrylates; naphtho[2; 1-b]furan-carboxylates

Sažetak
The multistep synthesis of a series of substituted amidino-benzimidazolyl-furyl-phenyl-acrylic acid`s esters and substituted amidino-benzimidazolyl-naphtho[2, 1-b]furan-carboxylic acid`s esters is described starting from corresponding 3-(2-furyl)-2-phenyl-acrylic acids. The new compounds were tested on the cytostatic activities against malignant cell lines: pancreatic carcinoma (MiaPaCa2), breast carcinoma (MCF7), cervical carcinoma (HeLa), laryngeal carcinoma (Hep2), colon carcinoma (HT 29), melanoma (HBL), and human fibroblast cell lines (WI-38). All compounds inhibited the proliferation of tumor cell lines. Inhibitory effect of examined compounds depended on cencentration, but without significant diference among the type of tumor cells. The compounds 2 and 5 exerted very low inhibitory effect on the growth of human fibroblasts.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
0098093
0125005

Ustanove
Institut "Ruđer Bošković", Zagreb,
Fakultet kemijskog inženjerstva i tehnologije, Zagreb

Časopis indeksira:


  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • CA Search (Chemical Abstracts)