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Pregled bibliografske jedinice broj: 1168985

Too nervous to sleep? Novel behavioral aspects of the intracerebroventricular streptozotocin- induced rat model of sporadic Alzheimer’s disease


Homolak, Jan; Virag, Davor; Babić Perhoč, Ana; Kodvanj, Ivan; Joja, Mihovil; Knezović, Ana; Osmanović Barilar, Jelena; Šalković-Petrišić, Melita
Too nervous to sleep? Novel behavioral aspects of the intracerebroventricular streptozotocin- induced rat model of sporadic Alzheimer’s disease // Abstracts of the WASAD Congress 2021: an International Congress of the World Association for Stress Related and Anxiety Disorders, held on 20–22 September 2021 in Vienna, Austria
Beč, Austrija: Springer Science and Business Media LLC, 2021. str. 1793-1793 doi:10.1007/s00702-021-02422-z (predavanje, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 1168985 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Too nervous to sleep? Novel behavioral aspects of the intracerebroventricular streptozotocin- induced rat model of sporadic Alzheimer’s disease

Autori
Homolak, Jan ; Virag, Davor ; Babić Perhoč, Ana ; Kodvanj, Ivan ; Joja, Mihovil ; Knezović, Ana ; Osmanović Barilar, Jelena ; Šalković-Petrišić, Melita

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the WASAD Congress 2021: an International Congress of the World Association for Stress Related and Anxiety Disorders, held on 20–22 September 2021 in Vienna, Austria / - : Springer Science and Business Media LLC, 2021, 1793-1793

Skup
WASAD Congress 2021: an International Congress of the World Association for Stress Related and Anxiety Disorders

Mjesto i datum
Beč, Austrija, 20-22.09.2021

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Alzheimer's disease ; streptozotocin ; circadian rhytm ; behavioral phenotype

Sažetak
Introduction: Alzheimer’s disease (AD) has been described more than 115 years ago, however, its etiopathogenesis remains unknown to date. Consequently, modeling of the disease in laboratory animals remains a challenge and the development of novel treatment solutions have been unsuccessful so far. Cognitive impairment is the most pronounced behavioral alteration present in both patients and animal models of the disease, nevertheless accompanying neuropsychiatric symptoms such as anxiety are often neglected and the behavioral complexity of current AD models remains largely unexplored. Considering neurobehavioral phenomena provide a unique insight into the pathophysiology of the central nervous system, acknowledgment of subtle behavioral changes may provide additional information indispensable for understanding the development of neuropathology in animal models. The present aim was to explore behavioral alterations accompanying deficits of learning and memory in the widely used intracerebroventricular streptozotocin (STZ-icv)-induced rat model of sporadic AD with a special focus directed to circadian alterations, stress response, and attention/impulsivity recently recognized as neglected behavioral and psychological symptoms often present in the early stage of the disease. Materials and methods: Independent cohorts of male Wistar rats treated with STZ-icv (3 mg/kg) and vehicle-treated controls have been studied. Acute and sub-acute circadian changes have been assessed by a custom-made circadian tracker—multi-cage infra-red open-source locomotor activity viewer (MIROSLAV). Acoustic startle and prepulse inhibition sensorimotor gating have been examined using the custom-made griPASTA platform. Open field test, social preference, novel object recognition, and passive avoidance have been used for assessment of general (anxiety, cognition, social preference, recognition memory, and associative learning) and subtle (attention dynamics, hesitancy/impulsivity) behavioral patterns. Results: Preliminary evidence suggests STZ-icv rats suffer from pronounced circadian dysrhythmia that develops already upon administration of the first dose of STZ-icv. Apart from well-known cognitive deficits, STZ-icv rats suffer from increased acoustic startle response with unaltered prepulse inhibition sensorimotor gating, increased anxiety accompanied by paradoxically increased exploration drive, and increased social preference. Furthermore, analysis of subtle behavioral patterns uncovers increased attention shifting and impulsivity in the STZ-icv rats. Conclusion: Deficits of learning and memory are well-known behavioral alterations present in the STZ-icv rats. Nevertheless, thorough exploration of the behavioral phenotype uncovers a complex pattern characterized by overlapping neurobehavioral phenomena that might provide a unique insight into the etiopathogenesis of STZ- icvinduced neurodegeneration with anxiety, altered stress response, and circadian dysrhythmia indicating the potential importance of the hypothalamus. Furthermore, acknowledgment of the behavioral complexity may uncover potential sources of bias and significantly contribute to the robustness and reliability of the results from the experiments exploiting the STZ-icv rat model of AD. This work was funded by the Croatian Science Foundation (IP-2018-01-8938). Research was co-financed by the Scientific Centre of Excellence for Basic, Clinical and Translational Neuroscience (project ‘‘Experimental and clinical research of hypoxic-ischemic damage in perinatal and adult brain’’ ; GA KK01.1.1.01.0007 funded by the European Union through the European Regional Development Fund).

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
IP-2018-01-8938 - Mehanizmi nutrijentom posredovanih učinaka endogenog glukagonu sličnog peptida-1 na kognitivne i metaboličke poremećaje u eksperimentalnim modelima neurodegenerativnih bolesti (NutrientGLP-1) (Šalković-Petrišić, Melita, HRZZ - 2018-01) ( POIROT)
EK-EFRR-KK.01.1.1.01.0007 - Eksperimentalna i klinička istraživanja hipoksijsko-ishemijskog oštećenja mozga u perinatalnoj i odrasloj dobi (Kostović, Ivica, EK - KK.01.1.1.01) ( POIROT)

Ustanove:
Medicinski fakultet, Zagreb

Poveznice na cjeloviti tekst rada:

Pristup cjelovitom tekstu rada doi link.springer.com

Citiraj ovu publikaciju:

Homolak, Jan; Virag, Davor; Babić Perhoč, Ana; Kodvanj, Ivan; Joja, Mihovil; Knezović, Ana; Osmanović Barilar, Jelena; Šalković-Petrišić, Melita
Too nervous to sleep? Novel behavioral aspects of the intracerebroventricular streptozotocin- induced rat model of sporadic Alzheimer’s disease // Abstracts of the WASAD Congress 2021: an International Congress of the World Association for Stress Related and Anxiety Disorders, held on 20–22 September 2021 in Vienna, Austria
Beč, Austrija: Springer Science and Business Media LLC, 2021. str. 1793-1793 doi:10.1007/s00702-021-02422-z (predavanje, međunarodna recenzija, sažetak, znanstveni)
Homolak, J., Virag, D., Babić Perhoč, A., Kodvanj, I., Joja, M., Knezović, A., Osmanović Barilar, J. & Šalković-Petrišić, M. (2021) Too nervous to sleep? Novel behavioral aspects of the intracerebroventricular streptozotocin- induced rat model of sporadic Alzheimer’s disease. U: Abstracts of the WASAD Congress 2021: an International Congress of the World Association for Stress Related and Anxiety Disorders, held on 20–22 September 2021 in Vienna, Austria doi:10.1007/s00702-021-02422-z.
@article{article, author = {Homolak, Jan and Virag, Davor and Babi\'{c} Perho\v{c}, Ana and Kodvanj, Ivan and Joja, Mihovil and Knezovi\'{c}, Ana and Osmanovi\'{c} Barilar, Jelena and \v{S}alkovi\'{c}-Petri\v{s}i\'{c}, Melita}, year = {2021}, pages = {1793-1793}, DOI = {10.1007/s00702-021-02422-z}, keywords = {Alzheimer's disease, streptozotocin, circadian rhytm, behavioral phenotype}, doi = {10.1007/s00702-021-02422-z}, title = {Too nervous to sleep? Novel behavioral aspects of the intracerebroventricular streptozotocin- induced rat model of sporadic Alzheimer’s disease}, keyword = {Alzheimer's disease, streptozotocin, circadian rhytm, behavioral phenotype}, publisher = {Springer Science and Business Media LLC}, publisherplace = {Be\v{c}, Austrija} }
@article{article, author = {Homolak, Jan and Virag, Davor and Babi\'{c} Perho\v{c}, Ana and Kodvanj, Ivan and Joja, Mihovil and Knezovi\'{c}, Ana and Osmanovi\'{c} Barilar, Jelena and \v{S}alkovi\'{c}-Petri\v{s}i\'{c}, Melita}, year = {2021}, pages = {1793-1793}, DOI = {10.1007/s00702-021-02422-z}, keywords = {Alzheimer's disease, streptozotocin, circadian rhytm, behavioral phenotype}, doi = {10.1007/s00702-021-02422-z}, title = {Too nervous to sleep? Novel behavioral aspects of the intracerebroventricular streptozotocin- induced rat model of sporadic Alzheimer’s disease}, keyword = {Alzheimer's disease, streptozotocin, circadian rhytm, behavioral phenotype}, publisher = {Springer Science and Business Media LLC}, publisherplace = {Be\v{c}, Austrija} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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