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Pregled bibliografske jedinice broj: 1168962

The Effect of Acute Oral Galactose Administration on the Redox System of the Rat Small Intestine


Homolak, Jan; Babic Perhoc, Ana; Knezovic, Ana; Osmanovic Barilar, Jelena; Virag, Davor; Joja, Mihovil; Salkovic-Petrisic, Melita
The Effect of Acute Oral Galactose Administration on the Redox System of the Rat Small Intestine // Antioxidants, 11 (2021), 1; 37, 24 doi:10.3390/antiox11010037 (međunarodna recenzija, članak, znanstveni)


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Naslov
The Effect of Acute Oral Galactose Administration on the Redox System of the Rat Small Intestine

Autori
Homolak, Jan ; Babic Perhoc, Ana ; Knezovic, Ana ; Osmanovic Barilar, Jelena ; Virag, Davor ; Joja, Mihovil ; Salkovic-Petrisic, Melita

Izvornik
Antioxidants (2076-3921) 11 (2021), 1; 37, 24

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
galactose ; oxidative stress ; gastrointestinal tract ; redox ; redox homeostasis

Sažetak
Galactose is a ubiquitous monosaccharide with important yet incompletely understood nutritive and physiological roles. Chronic parenteral d- galactose administration is used for modeling aging-related pathophysiological processes in rodents due to its ability to induce oxidative stress (OS). Conversely, chronic oral d-galactose administration prevents and alleviates cognitive decline in a rat model of sporadic Alzheimer’s disease, indicating that galactose may exert beneficial health effects by acting in the gut. The present aim was to explore the acute time- response of intestinal redox homeostasis following oral administration of d-galactose. Male Wistar rats were euthanized at baseline (n = 6), 30 (n = 6), 60 (n = 6), and 120 (n = 6) minutes following orogastric administration of d-galactose (200 mg/kg). The overall reductive capacity, lipid peroxidation, the concentration of low-molecular- weight thiols (LMWT) and protein sulfhydryls (SH), the activity of Mn and Cu/Zn superoxide dismutases (SOD), reduced and oxidized fractions of nicotinamide adenine dinucleotide phosphates (NADPH/NADP), and the hydrogen peroxide dissociation rate were analyzed in duodenum and ileum. Acute oral administration of d-galactose increased the activity of SODs and decreased intestinal lipid peroxidation and nucleophilic substrates (LMWT, SH, NADPH), indicating activation of peroxidative damage defense pathways. The redox system of the small intestine can acutely tolerate even high luminal concentrations of galactose (0.55 M), and oral galactose treatment is associated with a reduction rather than the increment of the intestinal OS. The ability of oral d-galactose to modulate intestinal OS should be further explored in the context of intestinal barrier maintenance, and beneficial cognitive effects associated with long- term administration of low doses of d-galactose.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
EK-EFRR-KK.01.1.1.01.0007 - Eksperimentalna i klinička istraživanja hipoksijsko-ishemijskog oštećenja mozga u perinatalnoj i odrasloj dobi (Kostović, Ivica, EK - KK.01.1.1.01) ( POIROT)
IP-2018-01-8938 - Mehanizmi nutrijentom posredovanih učinaka endogenog glukagonu sličnog peptida-1 na kognitivne i metaboličke poremećaje u eksperimentalnim modelima neurodegenerativnih bolesti (NutrientGLP-1) (Šalković-Petrišić, Melita, HRZZ - 2018-01) ( POIROT)

Ustanove:
Medicinski fakultet, Zagreb

Poveznice na cjeloviti tekst rada:

doi www.mdpi.com

Citiraj ovu publikaciju:

Homolak, Jan; Babic Perhoc, Ana; Knezovic, Ana; Osmanovic Barilar, Jelena; Virag, Davor; Joja, Mihovil; Salkovic-Petrisic, Melita
The Effect of Acute Oral Galactose Administration on the Redox System of the Rat Small Intestine // Antioxidants, 11 (2021), 1; 37, 24 doi:10.3390/antiox11010037 (međunarodna recenzija, članak, znanstveni)
Homolak, J., Babic Perhoc, A., Knezovic, A., Osmanovic Barilar, J., Virag, D., Joja, M. & Salkovic-Petrisic, M. (2021) The Effect of Acute Oral Galactose Administration on the Redox System of the Rat Small Intestine. Antioxidants, 11 (1), 37, 24 doi:10.3390/antiox11010037.
@article{article, author = {Homolak, Jan and Babic Perhoc, Ana and Knezovic, Ana and Osmanovic Barilar, Jelena and Virag, Davor and Joja, Mihovil and Salkovic-Petrisic, Melita}, year = {2021}, pages = {24}, DOI = {10.3390/antiox11010037}, chapter = {37}, keywords = {galactose, oxidative stress, gastrointestinal tract, redox, redox homeostasis}, journal = {Antioxidants}, doi = {10.3390/antiox11010037}, volume = {11}, number = {1}, issn = {2076-3921}, title = {The Effect of Acute Oral Galactose Administration on the Redox System of the Rat Small Intestine}, keyword = {galactose, oxidative stress, gastrointestinal tract, redox, redox homeostasis}, chapternumber = {37} }
@article{article, author = {Homolak, Jan and Babic Perhoc, Ana and Knezovic, Ana and Osmanovic Barilar, Jelena and Virag, Davor and Joja, Mihovil and Salkovic-Petrisic, Melita}, year = {2021}, pages = {24}, DOI = {10.3390/antiox11010037}, chapter = {37}, keywords = {galactose, oxidative stress, gastrointestinal tract, redox, redox homeostasis}, journal = {Antioxidants}, doi = {10.3390/antiox11010037}, volume = {11}, number = {1}, issn = {2076-3921}, title = {The Effect of Acute Oral Galactose Administration on the Redox System of the Rat Small Intestine}, keyword = {galactose, oxidative stress, gastrointestinal tract, redox, redox homeostasis}, chapternumber = {37} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


Citati:





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