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izvor podataka: crosbi

Wnt Signaling Pathway Is among the Drivers of Liver Metastasis (CROSBI ID 303303)

Prilog u časopisu | pregledni rad (znanstveni) | međunarodna recenzija

Samaržija, Ivana Wnt Signaling Pathway Is among the Drivers of Liver Metastasis // Livers, 1 (2021), 4; 180-200. doi: 10.3390/livers1040015

Podaci o odgovornosti

Samaržija, Ivana

engleski

Wnt Signaling Pathway Is among the Drivers of Liver Metastasis

Liver metastasis, originating either from a primary liver or other cancer types, represent a large cancer-related burden. Therefore, studies that add to better understanding of its molecular basis are needed. Herein, the role of the Wnt signaling pathway in liver metastasis is outlined. Its role in hepatocellular carcinoma (HCC) epithelial-mesenchymal transition (EMT), motility, migration, metastasis formation, and other steps of the metastatic cascade are presented. Additionally, the roles of the Wnt signaling pathway in the liver metastasis formation of colorectal, breast, gastric, lung, melanoma, pancreatic, and prostate cancer are explored. The special emphasis is given to the role of the Wnt signaling pathway in the communication between the many of the components of the primary and secondary cancer microenvironment that contribute to the metastatic outgrowth in the liver. The data presented herein are a review of the most recent publications and advances in the field that add to the idea that the Wnt pathway is among the drivers of liver metastasis and that its targeting could potentially relieve liver metastasis–related complications.

Wnt signaling pathway ; liver metastasis ; hepatocellular carcinoma ; colorectal cancer ; breast cancer ; gastric cancer ; lung cancer ; melanoma ; pancreatic cancer ; prostate cancer

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Podaci o izdanju

1 (4)

2021.

180-200

objavljeno

2673-4389

10.3390/livers1040015

Povezanost rada

Biologija

Poveznice