engleski

Synthesis, Structural Characterization and Antitumor Evaluation of Novel 1,2,3-triazole Derivatives of Benzoxazole

Cancer is the result of unwanted transformations of normal cells into tumor cells that can spread uncontrollably. It is a leading cause of death worldwide, accounting for nearly 10 million deaths in 2020. The most common types of cancer in 2020. were: breast (2, 26 million cases), lung (2, 21 million cases), colon (1, 93 million cases) and prostate cancer (1, 41 million cases). Because of its frequency and high mortality rate, there is an increased demand to develop new, potent antitumor agents. Benzoxazoles represent an important class of heterocyclic compounds that exhibit a variety of pharmacological activities such as anticancer, antibacterial, antiviral, antifungal, anti-inflammatory and more. [1-3] In order to evaluate their antitumor activity, novel benzoxazole derivatives with 1, 2, 3-triazole ring as a linker were prepared by conventional and green synthetic methods. Bezoxazole derivative linked with coumarin ring through 1, 2, 3-triazole showed the most potent activity against acute lymphoblastic leukemia (DND-41, IC50= 1 μM). [1] C. P. Kaushik, M. Chahal, .J. Chem. Sci, . 2020, 132:142 [2] U. Kamal, N. M. Javed, K. Arun, Asian J. Pharm. Clin. Res., 2020, 13, 1-14 [3] R. Sattar, R. Mukhtar, M. Atif, M. Hasnain, A. Irfan, J. Het. Chem., 2020, 57, 2079-2107

benzoxazole, click reaction, antitumor evaluations

nije evidentirano