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Pregled bibliografske jedinice broj: 1166557

Stable Gastric Pentadecapeptide BPC 157 Heals Established Vesicovaginal Fistula and Counteracts Stone Formation in Rats


Rašić, Domagoj; Zenko Sever, Anita; Rašić, Fran; Štrbe, Sanja; RaŠić, Žarko; Đuzel, Antonia; Duplančić, Božidar; Boban Blagaić, Alenka; Škrtić, Anita; Seiwerth, Sven et al.
Stable Gastric Pentadecapeptide BPC 157 Heals Established Vesicovaginal Fistula and Counteracts Stone Formation in Rats // Biomedicines, 9 (2021), 9; 1206, 20 doi:10.3390/biomedicines9091206 (međunarodna recenzija, članak, znanstveni)


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Naslov
Stable Gastric Pentadecapeptide BPC 157 Heals Established Vesicovaginal Fistula and Counteracts Stone Formation in Rats

Autori
Rašić, Domagoj ; Zenko Sever, Anita ; Rašić, Fran ; Štrbe, Sanja ; RaŠić, Žarko ; Đuzel, Antonia ; Duplančić, Božidar ; Boban Blagaić, Alenka ; Škrtić, Anita ; Seiwerth, Sven ; Sikirić, Predrag ; Sever, Marko

Izvornik
Biomedicines (2227-9059) 9 (2021), 9; 1206, 20

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
rats ; stable gastric pentadecapeptide BPC 157 ; stone formation ; vesicovaginal fistula

Sažetak
With the stable gastric pentadecapeptide BPC 157 therapy known to heal various both external and internal rat fistulas, we attempt to approach vesicovaginal fistula, continuous urine leaking through vagina, bladder stones, and a possible therapy solution among rats with well-formed 2 week-fistulas (vaginal/vesical 4 mm large defects) started with delayed therapy. Subsequent control fistula course (the subsequent 1, 2, 4, and 6 weeks) since beginning revealed the failed healing, fistula leaking, adhesions, urinary leaking through vagina, failed epithelization, collagenization, granulation tissue and neovascularization, increased inflammation, and necrosis. Thereby, the later intervals revealed the persistent inability to sustain even minimal volume, vesical, and vaginal defects and stone formation at the end of the experiment (fistula- time day 56). BPC 157 therapy (10 µg/kg, 10 ng/kg, intraperitoneally once time daily or perorally in drinking water until sacrifice) was initiated with a considerable delay (at 2 weeks after fistula formation). Already within 1 week therapy, all BPC 157 regimens stopped urinary leaking through vagina, reversed the otherwise resistant poor healing course to the increased epithelization, collagenization, granulation tissue and neovascularization, decreased inflammation, and decreased necrosis. Thereby, at later intervals, all BPC 157 rats exhibited a five times larger volume that can be sustained before leaking as in healthy, vesical, and vaginal defects completely closed and no stone formation. Thus, macro/microscopic and functional recovery, and counteracted stone formation. Concluding, BPC 157 therapy's beneficial effects resulted in healing and no stone formation, with µg- and ng-regimens, either given daily perorally in drinking water or intraperitoneally.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
Medicinski fakultet, Zagreb,
Medicinski fakultet, Split

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Rašić, Domagoj; Zenko Sever, Anita; Rašić, Fran; Štrbe, Sanja; RaŠić, Žarko; Đuzel, Antonia; Duplančić, Božidar; Boban Blagaić, Alenka; Škrtić, Anita; Seiwerth, Sven et al.
Stable Gastric Pentadecapeptide BPC 157 Heals Established Vesicovaginal Fistula and Counteracts Stone Formation in Rats // Biomedicines, 9 (2021), 9; 1206, 20 doi:10.3390/biomedicines9091206 (međunarodna recenzija, članak, znanstveni)
Rašić, D., Zenko Sever, A., Rašić, F., Štrbe, S., RaŠić, Ž., Đuzel, A., Duplančić, B., Boban Blagaić, A., Škrtić, A. & Seiwerth, S. (2021) Stable Gastric Pentadecapeptide BPC 157 Heals Established Vesicovaginal Fistula and Counteracts Stone Formation in Rats. Biomedicines, 9 (9), 1206, 20 doi:10.3390/biomedicines9091206.
@article{article, author = {Ra\v{s}i\'{c}, Domagoj and Zenko Sever, Anita and Ra\v{s}i\'{c}, Fran and \v{S}trbe, Sanja and Ra\v{S}i\'{c}, \v{Z}arko and \DJuzel, Antonia and Duplan\v{c}i\'{c}, Bo\v{z}idar and Boban Blagai\'{c}, Alenka and \v{S}krti\'{c}, Anita and Seiwerth, Sven and Sikiri\'{c}, Predrag and Sever, Marko}, year = {2021}, pages = {20}, DOI = {10.3390/biomedicines9091206}, chapter = {1206}, keywords = {rats, stable gastric pentadecapeptide BPC 157, stone formation, vesicovaginal fistula}, journal = {Biomedicines}, doi = {10.3390/biomedicines9091206}, volume = {9}, number = {9}, issn = {2227-9059}, title = {Stable Gastric Pentadecapeptide BPC 157 Heals Established Vesicovaginal Fistula and Counteracts Stone Formation in Rats}, keyword = {rats, stable gastric pentadecapeptide BPC 157, stone formation, vesicovaginal fistula}, chapternumber = {1206} }
@article{article, author = {Ra\v{s}i\'{c}, Domagoj and Zenko Sever, Anita and Ra\v{s}i\'{c}, Fran and \v{S}trbe, Sanja and Ra\v{S}i\'{c}, \v{Z}arko and \DJuzel, Antonia and Duplan\v{c}i\'{c}, Bo\v{z}idar and Boban Blagai\'{c}, Alenka and \v{S}krti\'{c}, Anita and Seiwerth, Sven and Sikiri\'{c}, Predrag and Sever, Marko}, year = {2021}, pages = {20}, DOI = {10.3390/biomedicines9091206}, chapter = {1206}, keywords = {rats, stable gastric pentadecapeptide BPC 157, stone formation, vesicovaginal fistula}, journal = {Biomedicines}, doi = {10.3390/biomedicines9091206}, volume = {9}, number = {9}, issn = {2227-9059}, title = {Stable Gastric Pentadecapeptide BPC 157 Heals Established Vesicovaginal Fistula and Counteracts Stone Formation in Rats}, keyword = {rats, stable gastric pentadecapeptide BPC 157, stone formation, vesicovaginal fistula}, chapternumber = {1206} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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