Viral Interactions with Adaptor-Protein Complexes: A Ubiquitous Trait among Viral Species (CROSBI ID 302592)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Strazic Geljic, Ivana ; Kucan Brlic, Paola ; Musak, Lucija ; Karner, Dubravka ; Ambriović- Ristov, Andreja ; Jonjic, Stipan ; Schu, Peter ; Rovis, Tihana Lenac
engleski
Viral Interactions with Adaptor-Protein Complexes: A Ubiquitous Trait among Viral Species
Numerous viruses hijack cellular protein trafficking pathways to mediate cell entry or to rearrange membrane structures thereby promoting viral replication and antagonizing the immune response. Adaptor protein complexes (AP), which mediate protein sorting in endocytic and secretory transport pathways, are one of the conserved viral targets with many viruses possessing AP- interacting motifs. We present here different mechanisms of viral interference with AP complexes and the functional consequences that allow for efficient viral propagation and evasion of host immune defense. The ubiquity of this phenomenon is evidenced by the fact that there are representatives for AP interference in all major viral families, covered in this review. The best described examples are interactions of human immunodeficiency virus and human herpesviruses with AP complexes. Several other viruses, like Ebola, Nipah, and SARS-CoV-2, are pointed out as high priority disease-causative agents supporting the need for deeper understanding of virus-AP interplay which can be exploited in the design of novel antiviral therapies.
adaptor protein complexes ; protein sorting ; endocytosis ; herpesviruses ; HIV ; respiratory viruses ; hemorrhagic fever viruses
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o izdanju
22 (10)
2021.
5274-5300
objavljeno
1422-0067
10.3390/ijms22105274
Povezanost rada
Biologija