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Viral Interactions with Adaptor-Protein Complexes: A Ubiquitous Trait among Viral Species (CROSBI ID 302592)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Strazic Geljic, Ivana ; Kucan Brlic, Paola ; Musak, Lucija ; Karner, Dubravka ; Ambriović- Ristov, Andreja ; Jonjic, Stipan ; Schu, Peter ; Rovis, Tihana Lenac Viral Interactions with Adaptor-Protein Complexes: A Ubiquitous Trait among Viral Species // International journal of molecular sciences, 22 (2021), 10; 5274-5300. doi: 10.3390/ijms22105274

Podaci o odgovornosti

Strazic Geljic, Ivana ; Kucan Brlic, Paola ; Musak, Lucija ; Karner, Dubravka ; Ambriović- Ristov, Andreja ; Jonjic, Stipan ; Schu, Peter ; Rovis, Tihana Lenac

engleski

Viral Interactions with Adaptor-Protein Complexes: A Ubiquitous Trait among Viral Species

Numerous viruses hijack cellular protein trafficking pathways to mediate cell entry or to rearrange membrane structures thereby promoting viral replication and antagonizing the immune response. Adaptor protein complexes (AP), which mediate protein sorting in endocytic and secretory transport pathways, are one of the conserved viral targets with many viruses possessing AP- interacting motifs. We present here different mechanisms of viral interference with AP complexes and the functional consequences that allow for efficient viral propagation and evasion of host immune defense. The ubiquity of this phenomenon is evidenced by the fact that there are representatives for AP interference in all major viral families, covered in this review. The best described examples are interactions of human immunodeficiency virus and human herpesviruses with AP complexes. Several other viruses, like Ebola, Nipah, and SARS-CoV-2, are pointed out as high priority disease-causative agents supporting the need for deeper understanding of virus-AP interplay which can be exploited in the design of novel antiviral therapies.

adaptor protein complexes ; protein sorting ; endocytosis ; herpesviruses ; HIV ; respiratory viruses ; hemorrhagic fever viruses

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Podaci o izdanju

22 (10)

2021.

5274-5300

objavljeno

1422-0067

10.3390/ijms22105274

Povezanost rada

Biologija

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