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Probiotics in clinical practice – a new concept in combating malnutrition in children and adolescents

Probiotics are increasingly applied to prevent and treat many infectious, immune related and gastrointestinal diseases. Although the mechanisms behind the putative effects are poorly understood, it has become clear that the intestinal microbiota plays an important role in maintaining health and thus is an attractive target for clinical interventions. There is a growing interest of scientists and clinicians in assessing the ability of probiotics to enhance the nutritional status of malnourished and children with non-communicable disease-associated malnutrition, since they are among the greatest global health problems of our time. We performed first randomised, double-blind, placebo-controlled study with Lactobacillus reuteri DSM17938 in children and adolescents with anorexia nervosa and constipation. L.reuteri DSM17938 was more effective than placebo in improving bowel movements and normalization of body weight in patients with AN, and showed positive trend considering the bone density recovery and vitaminD3 levels. We’re still in the relatively early stages of research into the microbiome. Over the next decades, we’re going to learn more about each individual microbial species and how they work with the food to impact health. This will allow us to smartly engineer interventions that correct the dysbiosis. Future possibilities implies the idea of personalising probiotic therapy, which contain tailored bacterial combinations that ensure optimal gut health what may affect the prevention and/or treatment of numerous diseases.

probiotics ; clinical practice ; anorexia nervosa ; constipation ; malnutrition

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