engleski

Utilisation patterns of group O red blood cell transfusion by ABO and D non-identical recipients in large academic hospital

Several studies have raised concerns that transfusion of O red blood cells (RBCs) to ABOand D non-identical recipients can intensify group O inventory shortages. The aim of this study was toretrospectively analyse particular clinical indications and polices responsible for O RBCs use by ABO andD non- identical recipients, as well as to assess the impact of this practice on the overall utilisation of ORBCs. Data of all transfused RBCs from 2014 to 2018 were extracted from the compre-hensive database of transfusion service. Extracted variables included date of transfusion, ABO and D groupof the transfused RBCs and recipients, recipient’s demographic, and specific characteristics regardingtransfusion requirements. Over a 5-year period, 124, 220 RBCs were transfused: 38, 962 (31.4%) group O D+ and 9109 (7.3%)group O D−. ABO and D non- identical recipient received 4842 (10.1%) of all administered O RBCs: 2880(7.4%) of all transfused O D+ and 1962 (21.5%) of all transfused O D− RBCs. The common indicationsfor this practice were: ABO and D mismatched hematopoietic stem cell transplantation (HSCT) (52.5%), infants under the age of 4 months (18.6%), shortage of ABO identical RBCs (9.0%), phenotype-matchedRBCs (8, 1%), and urgent transfusion (7.2%). A significant proportion of O RBCs was transfused to ABO and D non-identical recipients, mainly due to transfusion of ABO and D mismatched HSCT recipients. However, the proportion of alltransfused RBCs O D+ and especially O D− remained relatively low.

O RBCs ; ABO non-identical ; inventory ; transfusion

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