engleski

Platelet transfusion practice and related transfusion reactions in a large teaching hospital

Background. – Platelet transfusion practice varies widely since many aspects of platelet concentrate (PC)use have not been definitively determined. The objectives of this retrospective study were to presentplatelet transfusion practice and evaluate PC and patient characteristics, as well as their association withtransfusion reaction (TR) rate.Material and methods. – Platelet transfusions over a 5-year period were analysed regarding PC character-istics (the ABO and RhD compatibility, product type, and storage duration), patient characteristics (mostresponsible diagnosis, age, and gender), and TR type.Results. – A total of 46, 351 PCs were transfused: 76.4% whole blood-derived (WBD) and 23.6% singledonor apheresis (SDA). Three thousand seven hundred seventy-six patients received platelet transfu-sions: 24.7% paediatric and 75.3% adult patients, 79.6% outpatients and 20.4% inpatients. As much as63.1% of all transfused PCs were fresh (stored for ≤ 3 days), 98.0% ABO- identical, and 87.3% of all PCsgiven to RhD− patients were RhD−. PCs were mainly transfused to haemato-oncology (76.8%) and car- diovascular surgery patients (6.5%). Overall, 84 (0.18%) TRs were reported, with allergic TRs (ATRs) beingthe most common. Although PC ABO compatibility and storage duration, as well as patient age and gender, showed differences in TR rate, only the use of PCs in platelet additive solution (PAS) showed a statisticallysignificant reduction of TRs (P < 0.001).Conclusion. – Transfusion practice at the University Hospital Centre Zagreb resulted in almost all patientsreceiving ABO and RhD identical PCs, and most of them were fresh PCs. The most important factor affectingthe incidence of TRs was platelet storage solution. The use of PAS effectively reduced the rate of TRs, particularly allergic TRs.

ABO non-identical ; platelet concentrates ; platelet transfusion ; transfusion reaction

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