engleski

Artificial secondary structures in the design of new catalysts and new materials

In this conference paper, an author’s review in the field of bioinorganic chemistry, stereochemistry, homogeneous catalysis and medicinal inorganic chemistry is presented, with particular emphasis on physical chemistry aspects. Within this work, bioconjugates of amino acid containing phosphine or nitrogen ligands were utilized for metal coordination. The metal complexes were extensively characterized by a number of instrumental spectroscopic or crystallographic techniques and by DFT calculations. The metal complexes were used as catalysts in the selective preparation of intermediates in the synthesis of active pharmaceutical ingredients. Special attention was paid to the formation of specific supramolecular artificial secondary structures formed by the amino acid moieties that control the stereochemical outcome of the catalytic reactions. In addition, the metal complexes served as building blocks for supramolecular architectures as well as potent anticancer agents.

secondary structures ; supramolecular chemistry

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