engleski

Recurrence of tumor flare reaction in a chronic lymphocytic leukemia patient during chlorambucilrituximab treatment 6 years after lenalidomide

In chronic lymphocytic leukemia, tumor flare reactions, characterized by sudden increase in tumor lesions caused by host immune effector cell infiltration, have been described exclusively after treatment with immunomodulators, most frequently lenalidomide. Here we describe a patient who had recurrence of tumor flare 6 years after the initial event, during treatment with rituximab and chemotherapy. This case report suggests that lenalidomide causes a long-lasting effect on lymph node microenvironment and host T cells.

tumor flare reaction ; chronic lymphocytic leukemia ; rituximab ; lenalidomide

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