Structures of Two Novel penam Derivatives (CROSBI ID 712215)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Danilovski, Aleksandar ; Vinković, Mladen ; Herak Jure
engleski
Structures of Two Novel penam Derivatives
The X-ray structure analysis of both optically active penam derivatives (2S, 4S, 5R, 6S)-2-benzylcarbamoyl-6-bromo-3, 3-dimethyl-7-oxo-4-thia-1- azabicyclo[3.2.0]heptane-4-oxide, C~15~H~17~BrN~2~O~3~S.H~2~O (I), and (5R)-3-benzylimino-2-isopropylidene-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane, C~15~H~16~N~2~OS (II), have been determined in order to ascertain their absolute configuration. Both compounds adopted open-book conformation of fused beta-lactam and thiazolidine ring. The beta-lactam ring is in a distorted planar conformation while the thiazolidine ring is in an envelope conformation. Pyramidalisation effect of the N1 atom in both compounds has been characterised by nitrogen shift from the plane of its substituents of 0.344(5) and 0.350(5) %A in molecules A and B in compound (I), as well as of 0.410(5) %A in compound (II).
penam ; optically active ; x-ray crystallography ; conformation
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Podaci o prilogu
27-Book of Abstract.
1996.
objavljeno
Podaci o matičnoj publikaciji
Podaci o skupu
Fifth Slovenian-Croatian Crystallographic Meeting
poster
13.07.1996-15.07.1996
Ljubljana, Slovenija