engleski

PHOTOCATALYTIC BEHAVIOR OF ANTICANCER DRUGS: KINETIC STUDY AND TOXICITY ASSESEMENT

Drinking water supplies and water quality are increasingly affected by the presence of various classes of, until recently undetectable, micropollutants, including pharmaceuticals as one of the most important emerging environmental contaminants. One subcategory of pharmaceuticals that can enter and cause problems in various water resources through many pathways (hospital, effluents, sewage systems) are anticancer drugs. Due to their physicochemical properties leading to mobility and persistence in the aquatic environment, many of these substances with their metabolites can cause side effects on various organisms. It should also be noted that such components are often transformed or degraded by various biotic and abiotic processes, which may lead to the formation of more polar and toxic products compared to the parent drug. The elimination of small molecules by standard wastewater treatment is not efficient, so photocatalysis is often used to remove pharmaceuticals from water by generating reactive species. The aim of this research was to investigate the photocatalytic activity of imatinib and crizotinib, two anticancer drugs used in patients with leukemia and lung cancer, respectively. TiO2 immobilized on a glass fibers mesh was used as the photocatalyst. To obtain optimal process parameters for the removal of pharmaceuticals from the synthetic waters, the mutual influence of the micropollutant initial concentration under environmentally relevant pH values was investigated using the software Design- Expert. Toxicity evaluation was also investigated.

pharmaceuticals, photocatalysis, kinetic study, toxicity

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