engleski

Supramolecular Control of Reactivity in the Solid State

Mechanochemistry is becoming recognized as a technique because it can promote solid-state reactions quickly and quantitatively, even on a large scale, but is also enabling access to processes and products usually not feasible in solution [1, 2]. Multicomponent solids, like cocrystals have been recognized and used to execute solid state reactions selectively and efficiently. Building on these recent advances, herein we employ real-time in situ Raman spectroscopy monitoring [3, 4] to explore the possibilities of manipulating the reaction kinetics and chemical reactivity of the Knoevenagel condensation in solid state. We emphasize in particular reaction paths and product selectivity that can be explored in the solid state by applying principles of crystal engineering [5, 6] through the use of polymorphs, desmotropes, cocrystals, or salts.

mechanochemistry ; cocrystals ; salts ; desmotrpes ; polymorphs ; Knoevenagel condensation ; solid state reactions ; reaction kinetics

Poster napravljen prema radu: Kralj, Magdalena; Lukin, Stipe; Miletić, Goran; Halasz, Ivan. Using desmotropes, cocrystals and salts for manipulating reactivity in mechanochemical organic reactions // Journal of organic chemistry, 86 (2021), 20; 14160-14168 doi:10.1021/acs.joc.1c01817 https://www.bib.irb.hr/1141161