engleski

Pilot study of the therapeutic effect of Excipial U Lipolotion emulsion in radiotherapy patients with inflammatory skin reaction

During radiotherapy, inflammatory skin reaction develops to a lesser or greater extent in almost every patient. Transdermal moisture loss - skin dehydration, as one of the effects of irradiation, is favorable for the onset of inflamma- tory skin reactions, it enhances the symptoms and retards skin recovery. Excipial U Lipolotion, W/O emulsion with a 4% urea segment rehydrates the skin and decreases the transdermal moisture loss. In the past clinical studies, preparations with a 3-4% urea segment have proved to be efficient means of treating the inflammatory skin reactions. Based on that, we have conduced a study applying the Excipial U Lipolotion preparation on the skin of radiothe- rapy patients with explicit inflammatory skin reactions. Patients with head and neck cancers as well as breast cancer were included. The preparation's efficiency was evaluated upon a clinical review of the skin condition's subjective parameters by the physician and by questioning the patient whether or not the preparation was useful. We came to a conclusion that Excipial U Lipolotion has a favorable effect on the inflammatory skin reactions with a very distinct effect on the dry in- flammatory reactions. It also decreases subjective problems - irritation, burning, pain - to a greater extent in radiotherapy patients. Regarding the fact that the evaluation parameters were subjective, further research of the Excipial U Lipolotion effect is required, based on objective clinical indications - skin moisture degree during the preparation's application.

inflammatory skin reactions, Excipial U Lipolotion, radiotherapy, transdermal moisture loss

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