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Pregled bibliografske jedinice broj: 1164666

Immunohistochemical paterns IMP3, Ki-67, p53 and cyclin d1 in laryngeal carcinogenesis


Maržić, Diana; Čoklo, Miran; Marijić, Blažen; Radobuljac, Katarina; Čuš, Nina; Hadžisejdić, Ita; Radojčić, Milan; Šepić, Tatjana; Avirović, Manuela; Braut, Tamara
Immunohistochemical paterns IMP3, Ki-67, p53 and cyclin d1 in laryngeal carcinogenesis // 14th Croatian oncology congress / Vrdoljak, Eduard ; Jazvić, Marijana (ur.).
Zagreb, Croatia: University Hospital for Tumors, Zagreb, Croatia, 2021. str. 114-115 (poster, domaća recenzija, sažetak, znanstveni)


CROSBI ID: 1164666 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Immunohistochemical paterns IMP3, Ki-67, p53 and cyclin d1 in laryngeal carcinogenesis

Autori
Maržić, Diana ; Čoklo, Miran ; Marijić, Blažen ; Radobuljac, Katarina ; Čuš, Nina ; Hadžisejdić, Ita ; Radojčić, Milan ; Šepić, Tatjana ; Avirović, Manuela ; Braut, Tamara

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
14th Croatian oncology congress / Vrdoljak, Eduard ; Jazvić, Marijana - Zagreb, Croatia : University Hospital for Tumors, Zagreb, Croatia, 2021, 114-115

Skup
14th Croatian oncology congress

Mjesto i datum
Virtal congress, 22-25. 04. 2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
cyclin D1 ; immunohistochemical expression pattern ; IMP3 ; Ki-67 ; laryngeal carcinogenesis ; p53

Sažetak
There are only a few studies so far on IMP3 role as a potential diagnostic biomarker in the laryngeal carcinogenesis. Therefore, it makes sense to analyze IMP3 together with other biomarkers of carcinogenesis. The aim of this study was to investigate the immunohistochemical expression patterns of IMP3, Ki-67, p53 and cyclin D1 in laryngeal carcinogenesis. The study included 153 patients divided into three groups: 68 operated for primary invasive laryngeal squamous cell carcinoma (LSCC) ; 41 with precancerous lesions of atypical and abnormal hyperplasia and 44 with hyperplastic laryngeal nodule without atypia. Tissue microarray technique was used for immunohistochemical analysis. As for the IMP3 staining pattern, a cytoplasmic staining of low intensity in a few cells of superficial layers was found in both control and precancerosis groups. On the other hand, in tumor cells of LSCC there was a high percentage of cytoplasmic staining against IMP3 of high intensity. Additionally, IMP3 staining showed significant intertumoral and intratumoral heterogeneity in different cases of LSCC. In well- differentiated LSCC with present keratinization we noticed that negative areas of the tumor alternate with areas of cytoplasmic staining of low intensity. In tumor cells of moderately differentiated LSCC there was a pattern of combined focal cytoplasmic staining of strong intensity with cytoplasmic staining of low intensity, while a diffuse cytoplasmic staining of moderate to strong intensity was found in tumor cells of poorly differentiated LSCC. Ki67 staining showed a low percentage of nuclear staining of medium to high intensity against Ki-67 in parabasal and a few suprabasal layers of samples from both control and precancerosis groups. High percentage of nuclear staining of high intensity was found in samples from the LSCC group. p53 staining showed different patterns in all three groups. In control group, there was a low percentage of nuclear staining of moderate to strong intensity in parabasal and few suprabasal layers, while in precancerosis group it was medium percentage of nuclear staining of moderate to strong intensity in basal, parabasal and few suprabasal layers. In the LSCC group there was a high percentage of nuclear staining of moderate to strong intensity in tumor cells. Cyclin D1 showed a high percentage of nuclear staining of moderate to strong intensity in parabasal and few suprabasal layers of samples from the control group and in tumor cells of LSCC. However, in the precancerosis group there was a medium percentage of nuclear staining of moderate to strong intensity in a few basal, parabasal and several suprabasal layers. Immunohistochemical expressions of Ki-67 and pronouncedly IMP3 generally follow the same pattern where control and precancerosis are similar and LSCC significantly differs, as opposed to p53 and cyclin D1. In that sense, IMP3 expression increase and difference in LSCC, as opposed to control and precancerosis, is especially pronounced, which points toward its possibly important diagnostic, therapeutic and prognostic value.Further studies on the exact molecular mechanisms behind these differences are, of course, needed.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
NadSve-Sveučilište u Rijeci-uniri-biomed-18-121 - Molekularni biomarkeri kancerogeneze u skvamoznim epitelnim lezijama grkljana (Braut, Tamara, NadSve ) ( POIROT)

Ustanove:
Medicinski fakultet, Rijeka,
Institut za antropologiju,
Klinički bolnički centar Rijeka

Poveznice na cjeloviti tekst rada:

Hrčak

Citiraj ovu publikaciju:

Maržić, Diana; Čoklo, Miran; Marijić, Blažen; Radobuljac, Katarina; Čuš, Nina; Hadžisejdić, Ita; Radojčić, Milan; Šepić, Tatjana; Avirović, Manuela; Braut, Tamara
Immunohistochemical paterns IMP3, Ki-67, p53 and cyclin d1 in laryngeal carcinogenesis // 14th Croatian oncology congress / Vrdoljak, Eduard ; Jazvić, Marijana (ur.).
Zagreb, Croatia: University Hospital for Tumors, Zagreb, Croatia, 2021. str. 114-115 (poster, domaća recenzija, sažetak, znanstveni)
Maržić, D., Čoklo, M., Marijić, B., Radobuljac, K., Čuš, N., Hadžisejdić, I., Radojčić, M., Šepić, T., Avirović, M. & Braut, T. (2021) Immunohistochemical paterns IMP3, Ki-67, p53 and cyclin d1 in laryngeal carcinogenesis. U: Vrdoljak, E. & Jazvić, M. (ur.)14th Croatian oncology congress.
@article{article, author = {Mar\v{z}i\'{c}, Diana and \v{C}oklo, Miran and Mariji\'{c}, Bla\v{z}en and Radobuljac, Katarina and \v{C}u\v{s}, Nina and Had\v{z}isejdi\'{c}, Ita and Radoj\v{c}i\'{c}, Milan and \v{S}epi\'{c}, Tatjana and Avirovi\'{c}, Manuela and Braut, Tamara}, year = {2021}, pages = {114-115}, keywords = {cyclin D1, immunohistochemical expression pattern, IMP3, Ki-67, laryngeal carcinogenesis, p53}, title = {Immunohistochemical paterns IMP3, Ki-67, p53 and cyclin d1 in laryngeal carcinogenesis}, keyword = {cyclin D1, immunohistochemical expression pattern, IMP3, Ki-67, laryngeal carcinogenesis, p53}, publisher = {University Hospital for Tumors, Zagreb, Croatia}, publisherplace = {Virtal congress} }
@article{article, author = {Mar\v{z}i\'{c}, Diana and \v{C}oklo, Miran and Mariji\'{c}, Bla\v{z}en and Radobuljac, Katarina and \v{C}u\v{s}, Nina and Had\v{z}isejdi\'{c}, Ita and Radoj\v{c}i\'{c}, Milan and \v{S}epi\'{c}, Tatjana and Avirovi\'{c}, Manuela and Braut, Tamara}, year = {2021}, pages = {114-115}, keywords = {cyclin D1, immunohistochemical expression pattern, IMP3, Ki-67, laryngeal carcinogenesis, p53}, title = {Immunohistochemical paterns IMP3, Ki-67, p53 and cyclin d1 in laryngeal carcinogenesis}, keyword = {cyclin D1, immunohistochemical expression pattern, IMP3, Ki-67, laryngeal carcinogenesis, p53}, publisher = {University Hospital for Tumors, Zagreb, Croatia}, publisherplace = {Virtal congress} }




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