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izvor podataka: crosbi

Immunohistochemical expression of Wnt-4 protein in clear cell renal carcinoma (CROSBI ID 302221)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Pavlović, Oliver ; Hudolin, Tvrtko ; Miškulin, Ivan ; Bulimbašić, Stela ; Ćorić, Marijana ; Perković, Josip ; Zekulić, Toni Immunohistochemical expression of Wnt-4 protein in clear cell renal carcinoma // Journal of clinical medicine, 10 (2021), 24; 5795, 9. doi: 10.3390/jcm10245795

Podaci o odgovornosti

Pavlović, Oliver ; Hudolin, Tvrtko ; Miškulin, Ivan ; Bulimbašić, Stela ; Ćorić, Marijana ; Perković, Josip ; Zekulić, Toni

engleski

Immunohistochemical expression of Wnt-4 protein in clear cell renal carcinoma

Wingless binding integration site proteins (Wnt) have an important role in normal kidney development and in various kidney diseases. They are required for complete epithelial differentiation and normal nephron formation. Changes in these proteins could also have important role in carcinogenesis. This study included 185 patients with clear cell renal carcinoma (ccRCC) in whom immunohistochemical expression of Wnt-4 protein in healthy and tumorous tissue after surgery was investigated. There was higher expression of Wnt-4 in healthy than in tumor tissue. No difference between Fuhrman’s grade and Wnt-4 expression was found. A poor negative correlation between tumor size and Wnt-4 expression was found. Patients with suspected metastatic diseases had higher Wnt-4 expression. There was no difference in survival rates between Wnt-4 negative and positive groups. In our study we have shown that high Wnt-4 expression in healthy tissue decreases in low- grade tumors but then increases in high-grade tumors, suggesting that tumor progression requires Wnt-4 activation or reactivation.

clear cell renal carcinoma ; Wnt signaling pathway ; Wnt-4 protein ; immunohistochemistry

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Podaci o izdanju

10 (24)

2021.

5795

9

objavljeno

2077-0383

10.3390/jcm10245795

Povezanost rada

Javno zdravstvo i zdravstvena zaštita, Kliničke medicinske znanosti, Temeljne medicinske znanosti

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