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Pregled bibliografske jedinice broj: 1162594

Human Papillomavirus (HPV) Risk Group Patterns, Temporal Dynamics and Relationship with Abnormal Cervical Cytology Findings in Women during a 10- year Period: Elucidating the Significance of Low- risk/High-risk Co-Infection.


Meštrović, T.; Ljubin-Sternak, S.; Božičević, I.; Sviben, M.; Drenjančević, D.; Barać, A.; Neuberg, M.; Ribić, R.; Kozina , G.; Vraneš, J.
Human Papillomavirus (HPV) Risk Group Patterns, Temporal Dynamics and Relationship with Abnormal Cervical Cytology Findings in Women during a 10- year Period: Elucidating the Significance of Low- risk/High-risk Co-Infection. // FEMS Online Conference on Microbiology
Beograd, Srbija: Federation of European Microbiological Societies, 2020. str. 319-319 doi:10.26226/morressier.5f5b60612c3338b5c13cd23f (poster, međunarodna recenzija, sažetak, znanstveni)


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Naslov
Human Papillomavirus (HPV) Risk Group Patterns, Temporal Dynamics and Relationship with Abnormal Cervical Cytology Findings in Women during a 10- year Period: Elucidating the Significance of Low- risk/High-risk Co-Infection.

Autori
Meštrović, T. ; Ljubin-Sternak, S. ; Božičević, I. ; Sviben, M. ; Drenjančević, D. ; Barać, A. ; Neuberg, M. ; Ribić, R. ; Kozina , G. ; Vraneš, J.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
FEMS Online Conference on Microbiology / - : Federation of European Microbiological Societies, 2020, 319-319

ISBN
978-86-914897-6-2

Skup
FEMS Online Conference on Microbiology

Mjesto i datum
Beograd, Srbija, 28-30. 10. 2020

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Human Papillomavirus, Women, Low-risk/High-risk

Sažetak
Background and Objectives Human papillomavirus (HPV) represents a major risk factor for cervical dysplasia and invasive cervical cancer. Although most efforts are reasonably concentrated on high-risk HPV, we aimed to determine the overall and risk group-specific HPV patterns in a subset of women, as well as to evaluate the correlation of low-risk and/or high-risk HPV positivity with abnormal cervical cytological findings. Methods A convenience sample of 751 women (aged 18-67) visiting an outpatient clinic were simultaneously subjected to HPV DNA testing and cervical cytology evaluation during a 10-year period in Zagreb, Croatia. Specimens were screened with Digene HC2 HPV DNA Test (Qiagen Corporation, USA) for both low-risk and high-risk HPV risk groups. The cytology was reported using Bethesda system / “Zagreb 2002” classification. Statistical significance was set at p<0.05. Results In our cohort the overall HPV prevalence was 48.6%, and highest infection burden was in the 18- 30 age group (p=0.046). A decrease in low-risk and high-risk mono- positivity has been observed over the 10-year period ; conversely, there was a significant increase in low-risk/high-risk co- positivity (p=0.007). A co-infection with both low-risk and high-risk HPV prompted a compounding effect which increased the occurrence of abnormal cells and low grade squamous intraepithelial lesions (LSIL ; CIN I). Conclusions Our results have demonstrated that low-risk HPV has the propensity to act as a co-factor in the development of cytological abnormalities and LSIL, but not high grade squamous intraepithelial lesions (HSIL). If further longitudinal studies corroborate these findings, HPV testing that includes a broader gamut of HPV types may be justified.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita



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Citiraj ovu publikaciju:

Meštrović, T.; Ljubin-Sternak, S.; Božičević, I.; Sviben, M.; Drenjančević, D.; Barać, A.; Neuberg, M.; Ribić, R.; Kozina , G.; Vraneš, J.
Human Papillomavirus (HPV) Risk Group Patterns, Temporal Dynamics and Relationship with Abnormal Cervical Cytology Findings in Women during a 10- year Period: Elucidating the Significance of Low- risk/High-risk Co-Infection. // FEMS Online Conference on Microbiology
Beograd, Srbija: Federation of European Microbiological Societies, 2020. str. 319-319 doi:10.26226/morressier.5f5b60612c3338b5c13cd23f (poster, međunarodna recenzija, sažetak, znanstveni)
Meštrović, T., Ljubin-Sternak, S., Božičević, I., Sviben, M., Drenjančević, D., Barać, A., Neuberg, M., Ribić, R., Kozina , G. & Vraneš, J. (2020) Human Papillomavirus (HPV) Risk Group Patterns, Temporal Dynamics and Relationship with Abnormal Cervical Cytology Findings in Women during a 10- year Period: Elucidating the Significance of Low- risk/High-risk Co-Infection.. U: FEMS Online Conference on Microbiology doi:10.26226/morressier.5f5b60612c3338b5c13cd23f.
@article{article, author = {Me\v{s}trovi\'{c}, T. and Ljubin-Sternak, S. and Bo\v{z}i\v{c}evi\'{c}, I. and Sviben, M. and Drenjan\v{c}evi\'{c}, D. and Bara\'{c}, A. and Neuberg, M. and Ribi\'{c}, R. and Kozina, G. and Vrane\v{s}, J.}, year = {2020}, pages = {319-319}, DOI = {10.26226/morressier.5f5b60612c3338b5c13cd23f}, keywords = {Human Papillomavirus, Women, Low-risk/High-risk}, doi = {10.26226/morressier.5f5b60612c3338b5c13cd23f}, isbn = {978-86-914897-6-2}, title = {Human Papillomavirus (HPV) Risk Group Patterns, Temporal Dynamics and Relationship with Abnormal Cervical Cytology Findings in Women during a 10- year Period: Elucidating the Significance of Low- risk/High-risk Co-Infection.}, keyword = {Human Papillomavirus, Women, Low-risk/High-risk}, publisher = {Federation of European Microbiological Societies}, publisherplace = {Beograd, Srbija} }
@article{article, author = {Me\v{s}trovi\'{c}, T. and Ljubin-Sternak, S. and Bo\v{z}i\v{c}evi\'{c}, I. and Sviben, M. and Drenjan\v{c}evi\'{c}, D. and Bara\'{c}, A. and Neuberg, M. and Ribi\'{c}, R. and Kozina, G. and Vrane\v{s}, J.}, year = {2020}, pages = {319-319}, DOI = {10.26226/morressier.5f5b60612c3338b5c13cd23f}, keywords = {Human Papillomavirus, Women, Low-risk/High-risk}, doi = {10.26226/morressier.5f5b60612c3338b5c13cd23f}, isbn = {978-86-914897-6-2}, title = {Human Papillomavirus (HPV) Risk Group Patterns, Temporal Dynamics and Relationship with Abnormal Cervical Cytology Findings in Women during a 10- year Period: Elucidating the Significance of Low- risk/High-risk Co-Infection.}, keyword = {Human Papillomavirus, Women, Low-risk/High-risk}, publisher = {Federation of European Microbiological Societies}, publisherplace = {Beograd, Srbija} }

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