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izvor podataka: crosbi

Gastric cancer detection using the serum pepsinogen test method (CROSBI ID 301722)

Prilog u časopisu | ostalo | međunarodna recenzija

Trivanović, Dragan ; Pleština, Stjepko ; Honović, Lorena ; Dobrila-Dintinjana Renata ; Vlašić Tanasković Jelena ; Vrbanec Damir Gastric cancer detection using the serum pepsinogen test method // Tumori, 108 (2021), 4; 386-391. doi: 10.1177/03008916211014961

Podaci o odgovornosti

Trivanović, Dragan ; Pleština, Stjepko ; Honović, Lorena ; Dobrila-Dintinjana Renata ; Vlašić Tanasković Jelena ; Vrbanec Damir

engleski

Gastric cancer detection using the serum pepsinogen test method

Abstract Background: Gastric cancer (GC) is the eighth most common cause of cancer deaths in Croatia and one of the most common causes of cancer deaths worldwide. A reliable diagnostic tool for the early detection of GC is essential. Objective: We previously suggested a pepsinogen test method to reduce the mortality from GC by allowing early detection. Here, we report an updated analysis from a prospective single-center clinical study to evaluate the sensitivity and specificity of the pepsinogen test method and to determine whether this test can be used as a part of routine laboratory assessment of high-risk patients. Methods: We present mature data of the pepsinogen test method in the Croatian population after a median follow-up of 36 months. Statistical analyses were performed using a Mann-Whitney U test, multiple logistic regression, and receiver operating characteristics (ROC) to evaluate the predictive power of the assayed biomarkers. Results: Of the 116 patients, 25 patients had GC and 91 demonstrated a nonmalignant pathology based on tissue biopsy. Cutoff values were pepsinogen I ⩽70 and pepsinogen I/II ratio ⩽3.0. Using ROC curve analysis, the accuracy, sensitivity, specificity, positive predictive value, and negative predictive value were determined to be 87.22%, 78.12%, 90.10%, 71.43%, and 92.86%, respectively, for the diagnosis of GC. The area under the curve was 0.700 (95% confidence interval 0.57-0.83). Conclusion: Pepsinogen tests are valuable for screening a population in need of further diagnosis and could help to avoid unnecessary invasive endoscopic procedures.

Pepsinogen, ; gastric cancer ; serologic biopsy ; sensitivity ; specificity

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Podaci o izdanju

108 (4)

2021.

386-391

objavljeno

0300-8916

2038-2529

10.1177/03008916211014961

Povezanost rada

Kliničke medicinske znanosti

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