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Pregled bibliografske jedinice broj: 1161398

Disbalance of the duodenal epithelial cell turnover and apoptosis accompanies insensitivity of intestinal redox homeostasis to inhibition of the brain glucose-dependent insulinotropic polypeptide receptors in a rat model of sporadic Alzheimer's disease


Homolak, Jan; Babić Perhoč, Ana; Knežović, Ana; Osmanović Barilar, Jelena; Koc, Fatma; Stanton, Catherine; Ross, R. Paul; Šalković-Petrišić, Melita
Disbalance of the duodenal epithelial cell turnover and apoptosis accompanies insensitivity of intestinal redox homeostasis to inhibition of the brain glucose-dependent insulinotropic polypeptide receptors in a rat model of sporadic Alzheimer's disease // Neuroendocrinology (2021) doi:10.1159/000519988 (znanstveni, online first)


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Naslov
Disbalance of the duodenal epithelial cell turnover and apoptosis accompanies insensitivity of intestinal redox homeostasis to inhibition of the brain glucose-dependent insulinotropic polypeptide receptors in a rat model of sporadic Alzheimer's disease

Autori
Homolak, Jan ; Babić Perhoč, Ana ; Knežović, Ana ; Osmanović Barilar, Jelena ; Koc, Fatma ; Stanton, Catherine ; Ross, R. Paul ; Šalković-Petrišić, Melita

Vrsta, podvrsta
Radovi u časopisima, znanstveni

Izvornik
Neuroendocrinology (2021)

Status rada
Online first

Ključne riječi
Streptozotocin ; Alzheimer’s disease ; Intestine ; Brain-gut axis ; Intestinal barrier ; Glucose-dependent insulinotropic polypeptide ; Incretin ; Oxidative stress ; Apoptosis

Sažetak
Introduction: Gastrointestinal dyshomeostasis is investigated in the context of metabolic dysfunction, systemic, and neuroinflammation in Alzheimer’s disease. Dysfunctional gastrointestinal redox homeostasis and the brain- gut incretin axis have been reported in the rat model of insulin-resistant brain state- driven neurodegeneration induced by intracerebroventricular streptozotocin (STZ-icv). We aimed to assess whether (i) the structural epithelial changes accompany duodenal oxidative stress ; (ii) the brain glucose-dependent insulinotropic polypeptide receptor (GIP-R) regulates redox homeostasis of the duodenum ; and (iii) the STZ-icv brain-gut axis is resistant to pharmacological inhibition of the brain GIP-R. Methods: GIP-R inhibitor [Pro3]-GIP (85 μg/kg) was administered intracerebroventricularly to the control and the STZ-icv rats 1 month after model induction. Thiobarbituric acid reactive substances (TBARSs) were measured in the plasma and duodenum, and the sections were analyzed morphometrically. Caspase-3 expression and activation were assessed by Western blot and multiplex fluorescent signal amplification. Results: Intracerebroventricular [Pro3]-GIP decreased plasma TBARSs in the control and STZ-icv animals and increased duodenal TBARSs in the controls. In the controls, inhibition of brain GIP-R affected duodenal epithelial cells, but not villus structure, while all morphometric parameters were altered in the STZ-icv- treated animals. Morphometric changes in the STZ-icv animals were accompanied by reduced levels of caspase-3. Suppression of brain GIP-R inhibited duodenal caspase-3 activation. Conclusion: Brain GIP-R seems to be involved in the regulation of duodenal redox homeostasis and epithelial cell turnover. Resistance of the brain-gut GIP axis and morphological changes indicative of abnormal epithelial cell turnover accompany duodenal oxidative stress in the STZ-icv rats.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove:
Medicinski fakultet, Zagreb

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Homolak, Jan; Babić Perhoč, Ana; Knežović, Ana; Osmanović Barilar, Jelena; Koc, Fatma; Stanton, Catherine; Ross, R. Paul; Šalković-Petrišić, Melita
Disbalance of the duodenal epithelial cell turnover and apoptosis accompanies insensitivity of intestinal redox homeostasis to inhibition of the brain glucose-dependent insulinotropic polypeptide receptors in a rat model of sporadic Alzheimer's disease // Neuroendocrinology (2021) doi:10.1159/000519988 (znanstveni, online first)
Homolak, J., Babić Perhoč, A., Knežović, A., Osmanović Barilar, J., Koc, F., Stanton, C., Ross, R. & Šalković-Petrišić, M. (2021) Disbalance of the duodenal epithelial cell turnover and apoptosis accompanies insensitivity of intestinal redox homeostasis to inhibition of the brain glucose-dependent insulinotropic polypeptide receptors in a rat model of sporadic Alzheimer's disease. Prihvaćen za objavljivanje u Neuroendocrinology. [Preprint] doi:10.1159/000519988.
@unknown{unknown, author = {Homolak, Jan and Babi\'{c} Perho\v{c}, Ana and Kne\v{z}ovi\'{c}, Ana and Osmanovi\'{c} Barilar, Jelena and Koc, Fatma and Stanton, Catherine and Ross, R. Paul and \v{S}alkovi\'{c}-Petri\v{s}i\'{c}, Melita}, year = {2021}, DOI = {10.1159/000519988}, keywords = {Streptozotocin, Alzheimer’s disease, Intestine, Brain-gut axis, Intestinal barrier, Glucose-dependent insulinotropic polypeptide, Incretin, Oxidative stress, Apoptosis}, journal = {Neuroendocrinology}, doi = {10.1159/000519988}, title = {Disbalance of the duodenal epithelial cell turnover and apoptosis accompanies insensitivity of intestinal redox homeostasis to inhibition of the brain glucose-dependent insulinotropic polypeptide receptors in a rat model of sporadic Alzheimer's disease}, keyword = {Streptozotocin, Alzheimer’s disease, Intestine, Brain-gut axis, Intestinal barrier, Glucose-dependent insulinotropic polypeptide, Incretin, Oxidative stress, Apoptosis} }
@unknown{unknown, author = {Homolak, Jan and Babi\'{c} Perho\v{c}, Ana and Kne\v{z}ovi\'{c}, Ana and Osmanovi\'{c} Barilar, Jelena and Koc, Fatma and Stanton, Catherine and Ross, R. Paul and \v{S}alkovi\'{c}-Petri\v{s}i\'{c}, Melita}, year = {2021}, DOI = {10.1159/000519988}, keywords = {Streptozotocin, Alzheimer’s disease, Intestine, Brain-gut axis, Intestinal barrier, Glucose-dependent insulinotropic polypeptide, Incretin, Oxidative stress, Apoptosis}, journal = {Neuroendocrinology}, doi = {10.1159/000519988}, title = {Disbalance of the duodenal epithelial cell turnover and apoptosis accompanies insensitivity of intestinal redox homeostasis to inhibition of the brain glucose-dependent insulinotropic polypeptide receptors in a rat model of sporadic Alzheimer's disease}, keyword = {Streptozotocin, Alzheimer’s disease, Intestine, Brain-gut axis, Intestinal barrier, Glucose-dependent insulinotropic polypeptide, Incretin, Oxidative stress, Apoptosis} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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