Is galactose a hormetic sugar? Evidence from rat hippocampal redox regulatory network (CROSBI ID 301637)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Homolak, Jan ; Babić Perhoč, Ana ; Knežović, Ana ; Kodvanj, Ivan ; Virag, Davor ; Osmanović Barilar, Jelena ; Riederer, Peter ; Šalković‐Petrišić, Melita
engleski
Is galactose a hormetic sugar? Evidence from rat hippocampal redox regulatory network
Scope Galactose, a ubiquitous monosaccharide with incompletely understood physiology is often exploited for inducing oxidative-stress mediated aging in animals. Recent research demonstrates that galactose can conserve cellular function during periods of starvation and prevent/alleviate cognitive deficits in a rat model of sporadic Alzheimer's disease. The present aim is to examine the acute effects of oral galactose on the redox regulatory network (RRN). Methods and Results Rat plasma and hippocampal RRNs are analyzed upon acute orogastric gavage of galactose (200 mg kg‒ 1). No systemic RRN disbalance is observed ; however, a mild pro-oxidative shift accompanied by a paradoxical increment in tissue reductive capacity suggesting overcompensation of endogenous antioxidant systems is observed in the hippocampus. Galactose-induced increment of reductive capacity is accompanied by inflation of the hippocampal pool of nicotinamide adenine dinucleotide phosphates indicating ROS detoxification through disinhibition of the oxidative pentose phosphate pathway flux, reduced neuronal activity, and upregulation of Leloir pathway gatekeeper enzyme galactokinase-1. Conclusion Based on the observed findings, and in the context of previous work on galactose, a hormetic hypothesis of galactose is proposed suggesting that the protective effects may be inseparable from its pro-oxidative action at the biochemical level.
galactose ; hormesis ; oxidative stress ; pentose phosphate pathway ; antioxidant
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Podaci o izdanju
65 (21)
2021.
e2100400
17
objavljeno
1613-4125
1613-4133
10.1002/mnfr.202100400
Povezanost rada
Temeljne medicinske znanosti