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Pregled bibliografske jedinice broj: 1161394

Is Galactose a Hormetic Sugar? An Exploratory Study of the Rat Hippocampal Redox Regulatory Network


Homolak, Jan; Babić Perhoč, Ana; Knežović, Ana; Kodvanj, Ivan; Virag, Davor; Osmanović Barilar, Jelena; Riederer, Peter; Šalković‐Petrišić, Melita
Is Galactose a Hormetic Sugar? An Exploratory Study of the Rat Hippocampal Redox Regulatory Network // Molecular Nutrition & Food Research, 65 (2021), 21; e2100400, 17 doi:10.1002/mnfr.202100400 (međunarodna recenzija, članak, znanstveni)


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Naslov
Is Galactose a Hormetic Sugar? An Exploratory Study of the Rat Hippocampal Redox Regulatory Network

Autori
Homolak, Jan ; Babić Perhoč, Ana ; Knežović, Ana ; Kodvanj, Ivan ; Virag, Davor ; Osmanović Barilar, Jelena ; Riederer, Peter ; Šalković‐Petrišić, Melita

Izvornik
Molecular Nutrition & Food Research (1613-4125) 65 (2021), 21; E2100400, 17

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
galactose ; hormesis ; oxidative stress ; pentose phosphate pathway ; antioxidant

Sažetak
Scope Galactose, a ubiquitous monosaccharide with incompletely understood physiology is often exploited for inducing oxidative-stress mediated aging in animals. Recent research demonstrates that galactose can conserve cellular function during periods of starvation and prevent/alleviate cognitive deficits in a rat model of sporadic Alzheimer's disease. The present aim is to examine the acute effects of oral galactose on the redox regulatory network (RRN). Methods and Results Rat plasma and hippocampal RRNs are analyzed upon acute orogastric gavage of galactose (200 mg kg‒ 1). No systemic RRN disbalance is observed ; however, a mild pro-oxidative shift accompanied by a paradoxical increment in tissue reductive capacity suggesting overcompensation of endogenous antioxidant systems is observed in the hippocampus. Galactose-induced increment of reductive capacity is accompanied by inflation of the hippocampal pool of nicotinamide adenine dinucleotide phosphates indicating ROS detoxification through disinhibition of the oxidative pentose phosphate pathway flux, reduced neuronal activity, and upregulation of Leloir pathway gatekeeper enzyme galactokinase-1. Conclusion Based on the observed findings, and in the context of previous work on galactose, a hormetic hypothesis of galactose is proposed suggesting that the protective effects may be inseparable from its pro-oxidative action at the biochemical level.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove:
Medicinski fakultet, Zagreb

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Homolak, Jan; Babić Perhoč, Ana; Knežović, Ana; Kodvanj, Ivan; Virag, Davor; Osmanović Barilar, Jelena; Riederer, Peter; Šalković‐Petrišić, Melita
Is Galactose a Hormetic Sugar? An Exploratory Study of the Rat Hippocampal Redox Regulatory Network // Molecular Nutrition & Food Research, 65 (2021), 21; e2100400, 17 doi:10.1002/mnfr.202100400 (međunarodna recenzija, članak, znanstveni)
Homolak, J., Babić Perhoč, A., Knežović, A., Kodvanj, I., Virag, D., Osmanović Barilar, J., Riederer, P. & Šalković‐Petrišić, M. (2021) Is Galactose a Hormetic Sugar? An Exploratory Study of the Rat Hippocampal Redox Regulatory Network. Molecular Nutrition & Food Research, 65 (21), e2100400, 17 doi:10.1002/mnfr.202100400.
@article{article, author = {Homolak, Jan and Babi\'{c} Perho\v{c}, Ana and Kne\v{z}ovi\'{c}, Ana and Kodvanj, Ivan and Virag, Davor and Osmanovi\'{c} Barilar, Jelena and Riederer, Peter and \v{S}alkovi\'{c}‐Petri\v{s}i\'{c}, Melita}, year = {2021}, pages = {17}, DOI = {10.1002/mnfr.202100400}, chapter = {e2100400}, keywords = {galactose, hormesis, oxidative stress, pentose phosphate pathway, antioxidant}, journal = {Molecular Nutrition and Food Research}, doi = {10.1002/mnfr.202100400}, volume = {65}, number = {21}, issn = {1613-4125}, title = {Is Galactose a Hormetic Sugar? An Exploratory Study of the Rat Hippocampal Redox Regulatory Network}, keyword = {galactose, hormesis, oxidative stress, pentose phosphate pathway, antioxidant}, chapternumber = {e2100400} }
@article{article, author = {Homolak, Jan and Babi\'{c} Perho\v{c}, Ana and Kne\v{z}ovi\'{c}, Ana and Kodvanj, Ivan and Virag, Davor and Osmanovi\'{c} Barilar, Jelena and Riederer, Peter and \v{S}alkovi\'{c}‐Petri\v{s}i\'{c}, Melita}, year = {2021}, pages = {17}, DOI = {10.1002/mnfr.202100400}, chapter = {e2100400}, keywords = {galactose, hormesis, oxidative stress, pentose phosphate pathway, antioxidant}, journal = {Molecular Nutrition and Food Research}, doi = {10.1002/mnfr.202100400}, volume = {65}, number = {21}, issn = {1613-4125}, title = {Is Galactose a Hormetic Sugar? An Exploratory Study of the Rat Hippocampal Redox Regulatory Network}, keyword = {galactose, hormesis, oxidative stress, pentose phosphate pathway, antioxidant}, chapternumber = {e2100400} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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