Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 1161392

Failure of the Brain Glucagon-Like Peptide-1- Mediated Control of Intestinal Redox Homeostasis in a Rat Model of Sporadic Alzheimer’s Disease


Homolak, Jan; Babic Perhoc, Ana; Knezovic, Ana; Osmanovic Barilar, Jelena; Salkovic-Petrisic, Melita
Failure of the Brain Glucagon-Like Peptide-1- Mediated Control of Intestinal Redox Homeostasis in a Rat Model of Sporadic Alzheimer’s Disease // Antioxidants, 10 (2021), 7; 1118, 21 doi:10.3390/antiox10071118 (međunarodna recenzija, članak, ostalo)


CROSBI ID: 1161392 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Failure of the Brain Glucagon-Like Peptide-1- Mediated Control of Intestinal Redox Homeostasis in a Rat Model of Sporadic Alzheimer’s Disease

Autori
Homolak, Jan ; Babic Perhoc, Ana ; Knezovic, Ana ; Osmanovic Barilar, Jelena ; Salkovic-Petrisic, Melita

Izvornik
Antioxidants (2076-3921) 10 (2021), 7; 1118, 21

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, ostalo

Ključne riječi
GLP-1 ; streptozotocin ; Alzheimer’s disease ; oxidative stress ; brain-gut axis ; redox homeostasis

Sažetak
The gastrointestinal system may be involved in the etiopathogenesis of the insulin-resistant brain state (IRBS) and Alzheimer’s disease (AD). Gastrointestinal hormone glucagon-like peptide-1 (GLP-1) is being explored as a potential therapy as activation of brain GLP-1 receptors (GLP-1R) exerts neuroprotection and controls peripheral metabolism. Intracerebroventricular administration of streptozotocin (STZ-icv) is used to model IRBS and GLP-1 dyshomeostasis seems to be involved in the development of neuropathological changes. The aim was to explore (i) gastrointestinal homeostasis in the STZ-icv model (ii) assess whether the brain GLP-1 is involved in the regulation of gastrointestinal redox homeostasis and (iii) analyze whether brain-gut GLP-1 axis is functional in the STZ-icv animals. Acute intracerebroventricular treatment with exendin- 3(9-39)amide was used for pharmacological inhibition of brain GLP-1R in the control and STZ- icv rats, and oxidative stress was assessed in plasma, duodenum and ileum. Acute inhibition of brain GLP-1R increased plasma oxidative stress. TBARS were increased, and low molecular weight thiols (LMWT), protein sulfhydryls (SH), and superoxide dismutase (SOD) were decreased in the duodenum, but not in the ileum of the controls. In the STZ-icv, TBARS and CAT were increased, LMWT and SH were decreased at baseline, and no further increment of oxidative stress was observed upon central GLP-1R inhibition. The presented results indicate that (i) oxidative stress is increased in the duodenum of the STZ-icv rat model of AD, (ii) brain GLP-1R signaling is involved in systemic redox regulation, (iii) brain-gut GLP-1 axis regulates duodenal, but not ileal redox homeostasis, and iv) brain-gut GLP-1 axis is dysfunctional in the STZ-icv model.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove:
Medicinski fakultet, Zagreb

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Homolak, Jan; Babic Perhoc, Ana; Knezovic, Ana; Osmanovic Barilar, Jelena; Salkovic-Petrisic, Melita
Failure of the Brain Glucagon-Like Peptide-1- Mediated Control of Intestinal Redox Homeostasis in a Rat Model of Sporadic Alzheimer’s Disease // Antioxidants, 10 (2021), 7; 1118, 21 doi:10.3390/antiox10071118 (međunarodna recenzija, članak, ostalo)
Homolak, J., Babic Perhoc, A., Knezovic, A., Osmanovic Barilar, J. & Salkovic-Petrisic, M. (2021) Failure of the Brain Glucagon-Like Peptide-1- Mediated Control of Intestinal Redox Homeostasis in a Rat Model of Sporadic Alzheimer’s Disease. Antioxidants, 10 (7), 1118, 21 doi:10.3390/antiox10071118.
@article{article, author = {Homolak, Jan and Babic Perhoc, Ana and Knezovic, Ana and Osmanovic Barilar, Jelena and Salkovic-Petrisic, Melita}, year = {2021}, pages = {21}, DOI = {10.3390/antiox10071118}, chapter = {1118}, keywords = {GLP-1, streptozotocin, Alzheimer’s disease, oxidative stress, brain-gut axis, redox homeostasis}, journal = {Antioxidants}, doi = {10.3390/antiox10071118}, volume = {10}, number = {7}, issn = {2076-3921}, title = {Failure of the Brain Glucagon-Like Peptide-1- Mediated Control of Intestinal Redox Homeostasis in a Rat Model of Sporadic Alzheimer’s Disease}, keyword = {GLP-1, streptozotocin, Alzheimer’s disease, oxidative stress, brain-gut axis, redox homeostasis}, chapternumber = {1118} }
@article{article, author = {Homolak, Jan and Babic Perhoc, Ana and Knezovic, Ana and Osmanovic Barilar, Jelena and Salkovic-Petrisic, Melita}, year = {2021}, pages = {21}, DOI = {10.3390/antiox10071118}, chapter = {1118}, keywords = {GLP-1, streptozotocin, Alzheimer’s disease, oxidative stress, brain-gut axis, redox homeostasis}, journal = {Antioxidants}, doi = {10.3390/antiox10071118}, volume = {10}, number = {7}, issn = {2076-3921}, title = {Failure of the Brain Glucagon-Like Peptide-1- Mediated Control of Intestinal Redox Homeostasis in a Rat Model of Sporadic Alzheimer’s Disease}, keyword = {GLP-1, streptozotocin, Alzheimer’s disease, oxidative stress, brain-gut axis, redox homeostasis}, chapternumber = {1118} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


Citati:





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font