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Pregled bibliografske jedinice broj: 1161390

GLP-1 receptor – Do we really know what we’re looking at?


Homolak, Jan; Babic Perhoc, Ana; Knezovic, Ana; Osmanovic Barilar, Jelena; Salkovic-Petrisic, Melita
GLP-1 receptor – Do we really know what we’re looking at? // Acta Histochemica, 123 (2021), 5; 151732, 2 doi:10.1016/j.acthis.2021.151732 (međunarodna recenzija, članak, ostalo)


CROSBI ID: 1161390 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
GLP-1 receptor – Do we really know what we’re looking at?

Autori
Homolak, Jan ; Babic Perhoc, Ana ; Knezovic, Ana ; Osmanovic Barilar, Jelena ; Salkovic-Petrisic, Melita

Izvornik
Acta Histochemica (0065-1281) 123 (2021), 5; 151732, 2

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, ostalo

Ključne riječi
GLP-1 ; antibodies, research methodology

Sažetak
We read with great interest a recent comprehensive review covering the knowns and the unknowns of glucagon-like peptide-1 (GLP-1) by McLean et al. (McLean et al., 2020). GLP-1 is best known for its incretin effects first described in the 1980s that provided strong foundations for the development of GLP-1 targeting drugs and revolutionized pharmacotherapy of insulin resistance in the 2000s (Drucker et al., 2017). Nevertheless, as evident from (McLean et al., 2020), we can expect that the glory days of GLP-1 are far from over and that this incretin is going to be even more important for the doctors of tomorrow based on many of its relevant actions, especially in the cardiovascular and central nervous system. A review by McLean et al. (McLean et al., 2020) drew our attention not only because it covers a timely and captivating topic, but because it clearly emphasizes serious limitations and methodological caveats regarding GLP-1 receptor (GLP-1R) expression analysis. Failure to acknowledge methodological caveats either willfully or through ignorance far too often leads to misinterpretation of the results and formation of unjustified conclusions challenging to rectify once they pass under the peer-review radar, and unfortunately – they often do. In this letter, we wish to acknowledge the intention of McLean et al. (McLean et al., 2020) to warn the readers about the methodological drawbacks, especially those regarding the specificity and sensitivity of GLP- 1R antisera and supplement the „Caveats and limitations“ section (McLean et al., 2020) with our own experience and comment regarding bs-1559R anti-GLP-1R rabbit polyclonal antibody.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove:
Medicinski fakultet, Zagreb

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Homolak, Jan; Babic Perhoc, Ana; Knezovic, Ana; Osmanovic Barilar, Jelena; Salkovic-Petrisic, Melita
GLP-1 receptor – Do we really know what we’re looking at? // Acta Histochemica, 123 (2021), 5; 151732, 2 doi:10.1016/j.acthis.2021.151732 (međunarodna recenzija, članak, ostalo)
Homolak, J., Babic Perhoc, A., Knezovic, A., Osmanovic Barilar, J. & Salkovic-Petrisic, M. (2021) GLP-1 receptor – Do we really know what we’re looking at?. Acta Histochemica, 123 (5), 151732, 2 doi:10.1016/j.acthis.2021.151732.
@article{article, author = {Homolak, Jan and Babic Perhoc, Ana and Knezovic, Ana and Osmanovic Barilar, Jelena and Salkovic-Petrisic, Melita}, year = {2021}, pages = {2}, DOI = {10.1016/j.acthis.2021.151732}, chapter = {151732}, keywords = {GLP-1, antibodies, research methodology}, journal = {Acta Histochemica}, doi = {10.1016/j.acthis.2021.151732}, volume = {123}, number = {5}, issn = {0065-1281}, title = {GLP-1 receptor – Do we really know what we’re looking at?}, keyword = {GLP-1, antibodies, research methodology}, chapternumber = {151732} }
@article{article, author = {Homolak, Jan and Babic Perhoc, Ana and Knezovic, Ana and Osmanovic Barilar, Jelena and Salkovic-Petrisic, Melita}, year = {2021}, pages = {2}, DOI = {10.1016/j.acthis.2021.151732}, chapter = {151732}, keywords = {GLP-1, antibodies, research methodology}, journal = {Acta Histochemica}, doi = {10.1016/j.acthis.2021.151732}, volume = {123}, number = {5}, issn = {0065-1281}, title = {GLP-1 receptor – Do we really know what we’re looking at?}, keyword = {GLP-1, antibodies, research methodology}, chapternumber = {151732} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati:





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