engleski

Oral beta-lactam challenge test without antecedent skin testing in children with history of allergy to beta-lactam

Direct oral challenge was performed in patients with history of benign rash associated with beta- lactam antibiotic. Because detailed description of suspected allergic reaction could not be provided from all caregivers, all patients went specific IgE to amoxicillin and/or basophil degranulation test to culprit drug which was negative. 19 patients were included, average age 6 years and 1 month. In 17 patients suspected allergic reaction was caused by amoxicillin (AMX) ; 8 of which in combination with clavulanic acid, one with phenoxymethylpenicillin and one with cephalexin. A DPT involved open 3-step graded oral provocation test with AMX, time interval between the doses was 2h. The patients were monitored for 24h after challenge and were discharged with instructions to call in the event of a delayed reaction. After DPT there was no reaction in 89% of patients, one patient developed benign rash and one drug-induced enterocolitis syndrome.

beta lactam ; allergy ; oral provocation test

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