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Microvascular reactivity in hypertensive and apparently healthy individuals in a random sample of the adult population (Solin, Croatia) – preliminary data from research project Epidemiology of arterial hypertension and salt intake in Croatia (EH-UH 2)

Aim: The aim of the Epidemiology of arterial hypertension and salt intake in Croatia (EH-UH 2) project was to determine the prevalence, awareness, treatment and control of arterial hypertension in Croatia in a random, representative sample of the general adult population. Also, it aimed to assess the microvascular reactivity in the same representative sample of the general adult population, and to determine potential differences in microvascular reactivity between healthy and hypertensive individuals. Materials and Methods: These are preliminary data involving 39 subjects from Solin, Croatia, of whom 16 had diagnosed arterial hypertensive (HT) and the other 23 were apparently healthy individuals (AH). Forearm skin post-occlusive reactive hyperemia (PORH) following 1-min vascular occlusion was assessed by laser Doppler flowmetry (LDF) (MoorVMS-LDF, Axminster, UK) to assess change in overall microvascular reactivity. Blood flow in skin microcirculation was expressed in arbitrary perfusion units and determined by software calculating the area under the curve (AUC) during baseline flow, occlusion, and reperfusion (1 min period). The final result was the difference between the percentage of flow change during reperfusion and occlusion in relation to baseline (R–O% increase). Between- group differences in the PORH was tested with analysis of covariance (ANCOVA) with the age and sex as the covariate. Results: Among HT subjects there was 8 women and 8 men, with a median age of 58 (37 – 69) years, while among AH individuals, there was 14 women and 9 men, with a median age of 45 (24 – 65) years. Age- and sex-adjusted mean PORH was significantly lower in HT compared to AH individuals (PORH R-O% HT 138.5 ± 14.8 vs. AH 175.1 ± 11.9, P=0.046). Conclusion: Microvascular reactivity is significantly attenuated in hypertensive compared to apparently healthy individuals, independently of their sex and age, in a random sample of the adult population from Solin, Croatia. Keywords: microcirculation, endothelium, hypertension, healthy, laser Doppler flowmetry

5. HRVATSKI KONGRES O HIPERTENZIJI s međunarodnim sudjelovanjem

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