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Pregled bibliografske jedinice broj: 1160933

Association of the MAOB rs1799836 single nucleotide polymorphism and APOE ɛ4 allele in Alzheimer's disease


Babić Leko, Mirjana; Nikolac Perković, Matea; Nedić Erjavec, Gordana; Klepac, Nataša; Švob Štrac, Dubravka; Borovečki, Fran; Pivac, Nela; Hof, Patrick R.; Šimić, Goran
Association of the MAOB rs1799836 single nucleotide polymorphism and APOE ɛ4 allele in Alzheimer's disease // Current Alzheimer research, 18 (2021), 7; 585-594 doi:10.2174/1567205018666210917162843 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1160933 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Association of the MAOB rs1799836 single nucleotide polymorphism and APOE ɛ4 allele in Alzheimer's disease

Autori
Babić Leko, Mirjana ; Nikolac Perković, Matea ; Nedić Erjavec, Gordana ; Klepac, Nataša ; Švob Štrac, Dubravka ; Borovečki, Fran ; Pivac, Nela ; Hof, Patrick R. ; Šimić, Goran

Izvornik
Current Alzheimer research (1567-2050) 18 (2021), 7; 585-594

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
APOE ; Alzheimer's disease ; MAOB ; genetic biomarkers ; mild cognitive impairment ; polymorphisms

Sažetak
Background: The dopaminergic system is functionally compromised in Alzheimer's dis-ease (AD). The activity of monoamine oxidase B (MAOB), the enzyme involved in the degradation of dopamine, is increased during AD. Also, increased expression of MAOB occurs in the post-mortem hippocampus and neocortex of patients with AD. The MAOB rs1799836 polymorphism modulates MAOB transcription, consequently influencing protein translation and MAOB activity. We recently showed that cerebrospinal fluid levels of amyloid β1-42 are decreased in patients carry- ing the A allele in MAOB rs1799836 polymorphism. Objective: The present study compares MAOB rs1799836 polymorphism and APOE, the only con- firmed genetic risk factor for sporadic AD. Method: We included 253 participants, 127 of whom had AD, 57 had mild cognitive impairment, 11 were healthy controls, and 58 suffered from other primary causes of dementia. MAOB and APOE polymorphisms were determined using TaqMan SNP Genotyping Assays. Results: We observed that the frequency of APOE ɛ4/ɛ4 homozygotes and APOE ɛ4 carriers is sig- nificantly increased among patients carrying the AA MAOB rs1799836 genotype. Conclusion: These results indicate that the MAOB rs1799836 polymorphism is a potential genetic biomarker of AD and a potential target for the treatment of decreased dopaminergic transmission and cognitive deterioration in AD.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti, Psihologija, Kognitivna znanost (prirodne, tehničke, biomedicina i zdravstvo, društvene i humanističke znanosti)



POVEZANOST RADA


Ustanove:
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb

Poveznice na cjeloviti tekst rada:

doi www.eurekaselect.net

Citiraj ovu publikaciju:

Babić Leko, Mirjana; Nikolac Perković, Matea; Nedić Erjavec, Gordana; Klepac, Nataša; Švob Štrac, Dubravka; Borovečki, Fran; Pivac, Nela; Hof, Patrick R.; Šimić, Goran
Association of the MAOB rs1799836 single nucleotide polymorphism and APOE ɛ4 allele in Alzheimer's disease // Current Alzheimer research, 18 (2021), 7; 585-594 doi:10.2174/1567205018666210917162843 (međunarodna recenzija, članak, znanstveni)
Babić Leko, M., Nikolac Perković, M., Nedić Erjavec, G., Klepac, N., Švob Štrac, D., Borovečki, F., Pivac, N., Hof, P. & Šimić, G. (2021) Association of the MAOB rs1799836 single nucleotide polymorphism and APOE ɛ4 allele in Alzheimer's disease. Current Alzheimer research, 18 (7), 585-594 doi:10.2174/1567205018666210917162843.
@article{article, author = {Babi\'{c} Leko, Mirjana and Nikolac Perkovi\'{c}, Matea and Nedi\'{c} Erjavec, Gordana and Klepac, Nata\v{s}a and \v{S}vob \v{S}trac, Dubravka and Borove\v{c}ki, Fran and Pivac, Nela and Hof, Patrick R. and \v{S}imi\'{c}, Goran}, year = {2021}, pages = {585-594}, DOI = {10.2174/1567205018666210917162843}, keywords = {APOE, Alzheimer's disease, MAOB, genetic biomarkers, mild cognitive impairment, polymorphisms}, journal = {Current Alzheimer research}, doi = {10.2174/1567205018666210917162843}, volume = {18}, number = {7}, issn = {1567-2050}, title = {Association of the MAOB rs1799836 single nucleotide polymorphism and APOE ɛ4 allele in Alzheimer's disease}, keyword = {APOE, Alzheimer's disease, MAOB, genetic biomarkers, mild cognitive impairment, polymorphisms} }
@article{article, author = {Babi\'{c} Leko, Mirjana and Nikolac Perkovi\'{c}, Matea and Nedi\'{c} Erjavec, Gordana and Klepac, Nata\v{s}a and \v{S}vob \v{S}trac, Dubravka and Borove\v{c}ki, Fran and Pivac, Nela and Hof, Patrick R. and \v{S}imi\'{c}, Goran}, year = {2021}, pages = {585-594}, DOI = {10.2174/1567205018666210917162843}, keywords = {APOE, Alzheimer's disease, MAOB, genetic biomarkers, mild cognitive impairment, polymorphisms}, journal = {Current Alzheimer research}, doi = {10.2174/1567205018666210917162843}, volume = {18}, number = {7}, issn = {1567-2050}, title = {Association of the MAOB rs1799836 single nucleotide polymorphism and APOE ɛ4 allele in Alzheimer's disease}, keyword = {APOE, Alzheimer's disease, MAOB, genetic biomarkers, mild cognitive impairment, polymorphisms} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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