engleski

Moderate-to-vigorous physical activity is associated with higher bone mineral density in children with inflammatory bowel disease

Objectives: Decreased mineral bone density (BMD) and reduced lean body mass (LBM) are common amongst children with inflammatory bowel disease (IBD). The aim of our cross-sectional, observational study was to evaluate the relationship between BMD, body composition and physical activity (PA) in children with IBD in remission. Methods: Total body less head (TLBH) dual energy X-ray absorptiometry (DXA) was used to measure BMD, fat mass (FM) and lean body mass (LBM). Triaxial accelerometer for five consecutive days was used to objectivize PA. Results: 40 pediatric IBD patients in clinical remission (24 boys ; age 15.3 ± 0.4 years ; Crohn's disease (CD) n = 20, ulcerative colitis (UC) n = 18, inflammatory bowel disease-unclassified (IBD- U) n = 2) were recruited. Mean BMD was 0.940 g/cm2 and mean BMD Z-score was -0.42 ± 0.14. CD patients had significantly lower BMD than UC counterparts (p < 0.001). Average time spent in PA was 247.24 ± 16.71 min/day with 45.73 ± 8.22 min/day spent in moderate-to-vigorous PA (MVPA). We observed a significant positive correlation between the time spent in MVPA and BMD Z-score (p = 0.003) and LBM Z-score (p = 0.026). Multivariate analysis confirmed that the positive correlation of MVPA and BMD Z-score. There was no significant correlation between daily protein intake and BMD. Cumulative glucocorticoid dose negatively correlated with LBM Z-score (p = 0.003), but not with BMD Z-score (p = 0.069). Conclusions: This study points to a strong positive relationship between MVPA, LBM and BMD. Longitudinal studies are required in order to elucidate the modifiable processes that determine body health and favorable body composition.

inflammatory bowel disease ; children ; physical activity ; body composition ; bone mineral density

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