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Pregled bibliografske jedinice broj: 1160810

Luteolin ameliorates experimental colitis in mice through ERK-mediated suppression of inflammation, apoptosis and autophagy


Vukelić, Iva; Detel, Dijana; Batičić, Lara; Potočnjak, Iva; Domitrović, Robert
Luteolin ameliorates experimental colitis in mice through ERK-mediated suppression of inflammation, apoptosis and autophagy // Biochemical Insights into Molecular Mechanisms / Spasojević, Ivan (ur.).
Kragujevac, Srbija: Faculty of Chemistry, Serbian Biochemical Society, 2021. str. 135-135 (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 1160810 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Luteolin ameliorates experimental colitis in mice through ERK-mediated suppression of inflammation, apoptosis and autophagy

Autori
Vukelić, Iva ; Detel, Dijana ; Batičić, Lara ; Potočnjak, Iva ; Domitrović, Robert

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Biochemical Insights into Molecular Mechanisms / Spasojević, Ivan - Kragujevac, Srbija : Faculty of Chemistry, Serbian Biochemical Society, 2021, 135-135

Skup
Serbian Biochemical Society Tenth Conference with international participation: Biochemical Insights into Molecular Mechanisms

Mjesto i datum
Kragujevac, Srbija, 24.09.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Ulcerative colitis, Luteolin, MAPK, ERK inhibitor, Inflammation, Apoptosis, Autophagy

Sažetak
Ulcerative colitis (UC) is one of the major forms of inflammatory bowel disease with an increasing incidence and prevalence worldwide. It is a chronic remitting and relapsing disease that occurs spontaneously characterized by gastrointestinal symptoms, and significantly affects the quality of life1. Currently used treatments for UC are unsatisfactory due to various side effects, failure in the induction of remission and prevention of relapse, as well as high economic costs2. Recently, the use of natural compounds has become increasingly attractive in the prevention and treatment of various diseases, including UC. Luteolin (3′, 4′, 5, 7- tetrahydroxyflavone ; Lut) is a common flavonoid present in many edible plants that has been shown to have beneficial effects on various diseases3, however, its effect on UC has been poorly studied. In this study, we investigated the effect of Lut in the posttreatment and cotreatment of experimental colitis induced by dextran sulfate sodium (DSS) in mice. Lut attenuated clinical symptoms of DSS-induced colitis in mice by diminishing body weight loss and improving disease activity index, alleviated colon tissue damage, and reduced inflammation, apoptosis and autophagy. This effect was more pronounced when Lut was applied simultaneously with DSS. Additionally, the role of extracellular signal-regulated kinases 1/2 (ERK1/2) in the mechanism of action of Lut in experimental colitis was investigated as it was shown that Lut increased the activity of ERK1/2. Inhibition of ERK1/2 exacerbated the symptoms of DSS-induced colitis and diminished the protective effects of Lut as evidenced by worsening of inflammation and increased apoptosis and autophagy. Overall, the results of this study contributed to the elucidation of the underlying mechanism of action of Lut in experimental colitis and provided new mechanistic details underlying the antiinflammatory, antiapoptotic and antiautophagic effects of Lut through the activation of the ERK signaling pathway. In conclusion, the results suggest that Lut could be an effective therapeutic candidate for the treatment of UC, or a supplement to conventional therapy, although further clinical studies are required.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Profili:

Avatar Url Lara Batičić (autor)

Avatar Url Dijana Detel (autor)

Avatar Url Iva Potočnjak (autor)

Avatar Url Iva Vukelić (autor)

Avatar Url Robert Domitrović (autor)


Citiraj ovu publikaciju:

Vukelić, Iva; Detel, Dijana; Batičić, Lara; Potočnjak, Iva; Domitrović, Robert
Luteolin ameliorates experimental colitis in mice through ERK-mediated suppression of inflammation, apoptosis and autophagy // Biochemical Insights into Molecular Mechanisms / Spasojević, Ivan (ur.).
Kragujevac, Srbija: Faculty of Chemistry, Serbian Biochemical Society, 2021. str. 135-135 (poster, međunarodna recenzija, sažetak, znanstveni)
Vukelić, I., Detel, D., Batičić, L., Potočnjak, I. & Domitrović, R. (2021) Luteolin ameliorates experimental colitis in mice through ERK-mediated suppression of inflammation, apoptosis and autophagy. U: Spasojević, I. (ur.)Biochemical Insights into Molecular Mechanisms.
@article{article, editor = {Spasojevi\'{c}, I.}, year = {2021}, pages = {135-135}, keywords = {Ulcerative colitis, Luteolin, MAPK, ERK inhibitor, Inflammation, Apoptosis, Autophagy}, title = {Luteolin ameliorates experimental colitis in mice through ERK-mediated suppression of inflammation, apoptosis and autophagy}, keyword = {Ulcerative colitis, Luteolin, MAPK, ERK inhibitor, Inflammation, Apoptosis, Autophagy}, publisher = {Faculty of Chemistry, Serbian Biochemical Society}, publisherplace = {Kragujevac, Srbija} }
@article{article, editor = {Spasojevi\'{c}, I.}, year = {2021}, pages = {135-135}, keywords = {Ulcerative colitis, Luteolin, MAPK, ERK inhibitor, Inflammation, Apoptosis, Autophagy}, title = {Luteolin ameliorates experimental colitis in mice through ERK-mediated suppression of inflammation, apoptosis and autophagy}, keyword = {Ulcerative colitis, Luteolin, MAPK, ERK inhibitor, Inflammation, Apoptosis, Autophagy}, publisher = {Faculty of Chemistry, Serbian Biochemical Society}, publisherplace = {Kragujevac, Srbija} }




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