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Pregled bibliografske jedinice broj: 1160806

Coumarine derivatives as potential acetylcholinesterase inhibitors


Domagoj, Šubarić; Drago, Bešlo; Ivana, Majić; Dejan, Agić; Melita, Lončarić; Maja, Molnar; Vesna, Rastija
Coumarine derivatives as potential acetylcholinesterase inhibitors // Book of abstract 27 th Croatian meeting of chemists and chemical engineers
Zagreb: Croatian Chemical Society, 2021. str. 111-111 (poster, domaća recenzija, sažetak, znanstveni)


CROSBI ID: 1160806 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Coumarine derivatives as potential acetylcholinesterase inhibitors

Autori
Domagoj, Šubarić ; Drago, Bešlo ; Ivana, Majić ; Dejan, Agić ; Melita, Lončarić ; Maja, Molnar ; Vesna, Rastija

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of abstract 27 th Croatian meeting of chemists and chemical engineers / - Zagreb : Croatian Chemical Society, 2021, 111-111

Skup
27 th Croatian meeting of chemists and chemical engineers

Mjesto i datum
Veli Lošinj, Hrvatska, 5-8.10.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
coumarine ; acetylcholinesterase inhibition ; nematodes ; molecular docking
(acetylcholinesterase inhibition ; nematodes ; molecular docking)

Sažetak
Acetylcholinesterase inhibitors have been highly regarded as potential drugs for Alzheimer's disease treatment. Inhibitory properties of AChE inhibitors show great potential as active compounds in plant protection treatments, functioning as pesticides. 38 newly synthesized coumarin derivatives have been tested as potential acetylcholinesterase inhibitors by utilizing the Ellman protocol. The experiment was conducted on a 96-well microplate UV-Vis reader at a wavelength of 412 nm. Ligand-receptor interactions were observed by molecular docking. Inhibition activity results of the 38 compounds were compared to the obtained results of nematicidal activity study against two species of naturally occurring beneficial soil nematodes: Heterorhabditis bacteriophora and Steinernema feltiae. The highest inhibition activity against acetylcholinesterase was obtained by compound 19 (3-cyano-8- hydroxycoumarin) (78.21 % inhibition). The same compound has shown a very small percentage of mortality of nematodes: H. bacteriophora (20.75 %) and S. feltiae (11.25 %). The main interactions with amino acid residues in the binding site of acetylcholinesterase (PDB: 1eve) of compound 19 consists of conventional hydrogen bond (green) ; van der Waals (light green) ; and π–alkyl interactions.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Poljoprivreda (agronomija)



POVEZANOST RADA


Projekti:
HRZZ-UIP-2017-05-6593 - Zelene tehnologije u sintezi heterocikličkih spojeva (GREENNESS) (Molnar, Maja, HRZZ - 2017-05) ( POIROT)

Ustanove:
Fakultet agrobiotehničkih znanosti Osijek,
Prehrambeno-tehnološki fakultet, Osijek

Poveznice na cjeloviti tekst rada:

27hskiki.hkd.hr

Citiraj ovu publikaciju:

Domagoj, Šubarić; Drago, Bešlo; Ivana, Majić; Dejan, Agić; Melita, Lončarić; Maja, Molnar; Vesna, Rastija
Coumarine derivatives as potential acetylcholinesterase inhibitors // Book of abstract 27 th Croatian meeting of chemists and chemical engineers
Zagreb: Croatian Chemical Society, 2021. str. 111-111 (poster, domaća recenzija, sažetak, znanstveni)
Domagoj, Š., Drago, B., Ivana, M., Dejan, A., Melita, L., Maja, M. & Vesna, R. (2021) Coumarine derivatives as potential acetylcholinesterase inhibitors. U: Book of abstract 27 th Croatian meeting of chemists and chemical engineers.
@article{article, author = {Domagoj, \v{S}ubari\'{c} and Drago, Be\v{s}lo and Ivana, Maji\'{c} and Dejan, Agi\'{c} and Melita, Lon\v{c}ari\'{c} and Maja, Molnar and Vesna, Rastija}, year = {2021}, pages = {111-111}, keywords = {coumarine, acetylcholinesterase inhibition, nematodes, molecular docking}, title = {Coumarine derivatives as potential acetylcholinesterase inhibitors}, keyword = {coumarine, acetylcholinesterase inhibition, nematodes, molecular docking}, publisher = {Croatian Chemical Society}, publisherplace = {Veli Lo\v{s}inj, Hrvatska} }
@article{article, author = {Domagoj, \v{S}ubari\'{c} and Drago, Be\v{s}lo and Ivana, Maji\'{c} and Dejan, Agi\'{c} and Melita, Lon\v{c}ari\'{c} and Maja, Molnar and Vesna, Rastija}, year = {2021}, pages = {111-111}, keywords = {acetylcholinesterase inhibition, nematodes, molecular docking}, title = {Coumarine derivatives as potential acetylcholinesterase inhibitors}, keyword = {acetylcholinesterase inhibition, nematodes, molecular docking}, publisher = {Croatian Chemical Society}, publisherplace = {Veli Lo\v{s}inj, Hrvatska} }




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