Psoas muscle index at the time of diagnosis might reflect the prognosis of classical Hodgkinʼs lymphoma patients (CROSBI ID 301352)
Prilog u časopisu | kratko priopćenje | međunarodna recenzija
Podaci o odgovornosti
Lucijanić, Marko ; Huzjan Korunić, Renata ; Ivić, Marija ; Fazlić Džankić, Amina ; Jonjić, Željko ; Mitrović, Zdravko ; Prka, Željko ; Piršić, Mario ; Jakšić, Ozren ; Gaćina, Petar ; Vlasac Glasnović, Josipa ; Pejša, Vlatko
engleski
Psoas muscle index at the time of diagnosis might reflect the prognosis of classical Hodgkinʼs lymphoma patients
We retrospectively investigated clinical and prognostic significance of psoas muscle index (PMI) calculated as total psoas muscle area at L3 vertebra level obtained from baseline computed tomography (CT) scans in 49 newly diagnosed classical Hodgkin's lymphoma (cHL) patients prior to specific treatment. Median PMI was 572.5 mm2/m2 and was significantly higher in males (P < 0.001), patients with higher body mass index (BMI, P < 0.001), absence of extranodal disease (P = 0.037), higher absolute lymphocyte count (P = 0.037), higher hemoglobin (P = 0.010) and lower lactate dehydrogenase (LDH, P = 0.050). There were no significant associations with age, disease subtype, presence of constitutional symptoms, Ann Arbor disease stage, presence of advanced disease or international prognostic score. Patients with lower PMI had significantly worse PFS (hazard ratio [HR] 4.91 ; P = 0.009). This phenomenon persisted in the multivariate model (HR = 5.09 ; P = 0.042) adjusted for International Prognostic Score (IPS) and chemotherapy type.
Lymphoproliferative neoplasm ; Prognostication ; Progression ; Sarcopenia ; Survival.
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Podaci o izdanju
134 (1-2)
2022.
80-82
objavljeno
0043-5325
1613-7671
10.1007/s00508-021-01850-x
Povezanost rada
Kliničke medicinske znanosti