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Pregled bibliografske jedinice broj: 1159875

Distribution of TERT promotor mutation in regard to clinical presentation of papillary thyroid cancer


Blažeković, Ivan; Romić, Matija; Periša, Josipa; Nižetić, Mia; Franceschi, Maja; Jukić, Tomislav; Šamija, Ivan; Kusić, Zvonko
Distribution of TERT promotor mutation in regard to clinical presentation of papillary thyroid cancer // 10th International Congress of the Croatian Society of Nuclear Medicine
Vodice, Hrvatska, 2021. str. /-/ (poster, recenziran, sažetak, znanstveni)


CROSBI ID: 1159875 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Distribution of TERT promotor mutation in regard to clinical presentation of papillary thyroid cancer

Autori
Blažeković, Ivan ; Romić, Matija ; Periša, Josipa ; Nižetić, Mia ; Franceschi, Maja ; Jukić, Tomislav ; Šamija, Ivan ; Kusić, Zvonko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
10th International Congress of the Croatian Society of Nuclear Medicine

Mjesto i datum
Vodice, Hrvatska, 03.09.2021. - 05.09.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Recenziran

Ključne riječi
thyroid cancer ; prognostic markers ; TERT promoter mutations

Sažetak
Papillary thyroid cancer (PTC) is the most common endocrine cancer. Clinicopathological features of PTC used for disease staging and treatment planning could be altered due to acquired mutations during tumor development. TERT promotor mutations are suggested to have a potential role in the dedifferentiation on PTC with a possible effect on its aggressiveness. The aim of this study is to analyse TERT promotor mutation in relation to clinicopathological characteristics of PTC patients. This retrospective study included 77 subjects (32 male, 42 female) with confirmed PTC whose data were obtained from the Dpt. of Oncology and Nuclear Medicine, Sestre milosrdnice UHC, Croatia. The study population consisted of 26 patients without PTC dissemination, 35 with local and 16 with distant metastasis. DNA was isolated from formalin-fixed paraffin-embedded samples and Sanger sequencing of the TERT promotor region was performed. In this study, 9.5% of cases (7/74) carried a hotspot mutation in the TERT promotor, which is in accordance with literature data. In 6 cases the most comon c124C>T (8.11%) mutation was detected, and in 2 cases the c146C>T mutation was present. Described TERT mutations did not significantly correlate with PTC dissemination stage. However, TERT mutation was significantly more often present in older female population (p<0, 001). Other detected variants were of unknown clinical significance, with the most common c105C>T, c106C>T and c107C>T, as well as c127C>T and c148C>T, in close proximity to the hotspot variants. Although men presented with statistically significant more aggressive disease, TERT mutation does not significantly correlate with PTC dissemination regardless of sex and age of diagnosis. Nevertheless, TERT mutation in females was exclusively present in older age group (>55) supporting that TERT promotor mutation is a late genetic event in tumors that progressively lose differentiation and are aggressive in nature.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
HRZZ-IP-2019-04-1130 - Genetski i epigenetski biljezi kao pokazatelji agresivnosti diferenciranog karcinoma štitnjače (ThyroGeneMark) (Kusić, Zvonko, HRZZ - 2019-04) ( CroRIS)

Ustanove:
KBC "Sestre Milosrdnice"


Citiraj ovu publikaciju:

Blažeković, Ivan; Romić, Matija; Periša, Josipa; Nižetić, Mia; Franceschi, Maja; Jukić, Tomislav; Šamija, Ivan; Kusić, Zvonko
Distribution of TERT promotor mutation in regard to clinical presentation of papillary thyroid cancer // 10th International Congress of the Croatian Society of Nuclear Medicine
Vodice, Hrvatska, 2021. str. /-/ (poster, recenziran, sažetak, znanstveni)
Blažeković, I., Romić, M., Periša, J., Nižetić, M., Franceschi, M., Jukić, T., Šamija, I. & Kusić, Z. (2021) Distribution of TERT promotor mutation in regard to clinical presentation of papillary thyroid cancer. U: 10th International Congress of the Croatian Society of Nuclear Medicine.
@article{article, author = {Bla\v{z}ekovi\'{c}, Ivan and Romi\'{c}, Matija and Peri\v{s}a, Josipa and Ni\v{z}eti\'{c}, Mia and Franceschi, Maja and Juki\'{c}, Tomislav and \v{S}amija, Ivan and Kusi\'{c}, Zvonko}, year = {2021}, pages = {/-/}, keywords = {thyroid cancer, prognostic markers, TERT promoter mutations}, title = {Distribution of TERT promotor mutation in regard to clinical presentation of papillary thyroid cancer}, keyword = {thyroid cancer, prognostic markers, TERT promoter mutations}, publisherplace = {Vodice, Hrvatska} }
@article{article, author = {Bla\v{z}ekovi\'{c}, Ivan and Romi\'{c}, Matija and Peri\v{s}a, Josipa and Ni\v{z}eti\'{c}, Mia and Franceschi, Maja and Juki\'{c}, Tomislav and \v{S}amija, Ivan and Kusi\'{c}, Zvonko}, year = {2021}, pages = {/-/}, keywords = {thyroid cancer, prognostic markers, TERT promoter mutations}, title = {Distribution of TERT promotor mutation in regard to clinical presentation of papillary thyroid cancer}, keyword = {thyroid cancer, prognostic markers, TERT promoter mutations}, publisherplace = {Vodice, Hrvatska} }




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