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Pregled bibliografske jedinice broj: 1159872

Novel iminocoumarin derived imidazo[4,5-b]pyridines as potential pH sensors


Boček, Ida; Vianello, Robert; Hranjec, Marijana
Novel iminocoumarin derived imidazo[4,5-b]pyridines as potential pH sensors // 27th Croatian Meeting of Chemists and Chemical Engineers : Book of abstracts / Marković, Dean ; Meštrović, Ernest ; Namjesnik, Danijel ; Tomašić, Vesna (ur.).
Zagreb: Croatian Chemical Society, 2021. str. 145-145 (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 1159872 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Novel iminocoumarin derived imidazo[4,5-b]pyridines as potential pH sensors

Autori
Boček, Ida ; Vianello, Robert ; Hranjec, Marijana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
27th Croatian Meeting of Chemists and Chemical Engineers : Book of abstracts / Marković, Dean ; Meštrović, Ernest ; Namjesnik, Danijel ; Tomašić, Vesna - Zagreb : Croatian Chemical Society, 2021, 145-145

Skup
27th Croatian Meeting of Chemists and Chemical Engineers

Mjesto i datum
Veli Lošinj, Hrvatska, 05.-08.10.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
imidazo[4, 5-b]pyridines ; iminocoumarines ; pH sensors, spectroscopic characterization ; computational chemistry

Sažetak
Benzazoles and coumarins are among the most privileged heterocyclic subunits in the medicinal chemistry due to their wide range of bioactivity. Iminocoumarine derivatives are known for their interesting spectroscopic properties as well as their application as fluorescent sensors. Monitoring pH range is crucial for studying many biological processes in live cell organelles. Conjugates of benzazoles and iminocoumarins are already being explored for pH sensing applications due to excellent spectroscopic response in correlation with pH value. This work presents the synthesis and spectroscopic characterization of novel iminocoumarine derived imidazo[4, 5- b]pyridines. Main percursor, 2- cyanomethylimidazo[4, 5-b]pyridine, was prepared in the cyclocondensation reaction with 2- cyanoacetamide, while targeted iminocoumarine derivatives were prepared in condensation with chosen 5-substituted salycil benzaldehydes. Nitro- substituted iminocoumarin was further condensed with 5-nitrosalycilbenzaldehid in order to explore additional conjugation on spectroscopic and pH sensing properties. The structures of newly prepared compounds were confirmed by means of 1H and 13C NMR spectroscopy as well as MS spectrometry. pH spectroscopic titrations will be performed in order to determine possible application as pH sensors in solutions followed by determination of pKa values experimentally as well as by computational approaches.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekti:
HRZZ-IP-2020-02-8090 - Dizajn, sinteza i računalna analiza novih optičkih kemijskih pH osjetilnih derivata benzazola (BenzpHSens) (Vianello, Robert, HRZZ - 2020-02) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Fakultet kemijskog inženjerstva i tehnologije, Zagreb

Profili:

Avatar Url Robert Vianello (autor)

Avatar Url Marijana Hranjec (autor)

Avatar Url Ida Boček (autor)

Poveznice na cjeloviti tekst rada:

Pristup cjelovitom tekstu rada 27hskiki.hkd.hr

Citiraj ovu publikaciju:

Boček, Ida; Vianello, Robert; Hranjec, Marijana
Novel iminocoumarin derived imidazo[4,5-b]pyridines as potential pH sensors // 27th Croatian Meeting of Chemists and Chemical Engineers : Book of abstracts / Marković, Dean ; Meštrović, Ernest ; Namjesnik, Danijel ; Tomašić, Vesna (ur.).
Zagreb: Croatian Chemical Society, 2021. str. 145-145 (poster, međunarodna recenzija, sažetak, znanstveni)
Boček, I., Vianello, R. & Hranjec, M. (2021) Novel iminocoumarin derived imidazo[4,5-b]pyridines as potential pH sensors. U: Marković, D., Meštrović, E., Namjesnik, D. & Tomašić, V. (ur.)27th Croatian Meeting of Chemists and Chemical Engineers : Book of abstracts.
@article{article, author = {Bo\v{c}ek, Ida and Vianello, Robert and Hranjec, Marijana}, year = {2021}, pages = {145-145}, keywords = {imidazo[4, 5-b]pyridines, iminocoumarines, pH sensors, spectroscopic characterization, computational chemistry}, title = {Novel iminocoumarin derived imidazo[4,5-b]pyridines as potential pH sensors}, keyword = {imidazo[4, 5-b]pyridines, iminocoumarines, pH sensors, spectroscopic characterization, computational chemistry}, publisher = {Croatian Chemical Society}, publisherplace = {Veli Lo\v{s}inj, Hrvatska} }
@article{article, author = {Bo\v{c}ek, Ida and Vianello, Robert and Hranjec, Marijana}, year = {2021}, pages = {145-145}, keywords = {imidazo[4, 5-b]pyridines, iminocoumarines, pH sensors, spectroscopic characterization, computational chemistry}, title = {Novel iminocoumarin derived imidazo[4,5-b]pyridines as potential pH sensors}, keyword = {imidazo[4, 5-b]pyridines, iminocoumarines, pH sensors, spectroscopic characterization, computational chemistry}, publisher = {Croatian Chemical Society}, publisherplace = {Veli Lo\v{s}inj, Hrvatska} }




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