Synthesis and bilogical activity of novel amidino- substituted benzimidazoles and benzothiazoles (CROSBI ID 710896)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | domaća recenzija
Podaci o odgovornosti
Beč, Anja ; Žonja, Lucija ; Hranjec, Marijana ; Starčević, Kristina ; Persoons, Leentje ; Daelemans, Dirk
engleski
Synthesis and bilogical activity of novel amidino- substituted benzimidazoles and benzothiazoles
Benzimidazole and benzothiazole are important scaffolds in pharmaceutical applications, associated with a wide variety of medicinal and biological activities. Amidine substituents at the termini of the molecule seem to contribute significantly to the molecule - possible biological target complex stability through H- bonding and electrostatic interactions [1]. This work presents the synthesis of novel amidino- substituted coumarine derived benzimidazoles and benzothiazoles as hydrochloride salts. Target compounds were prepared by conventional reactions of organic syntheses as well as by microwave assisted reactions. The synthesized compounds were explored for their antioxidative activity in vitro by using three biological assays, namely DPPH, FRAP and ABTS, as well as antiproliferative activity on several human cancer cells in vitro [2].
benzimidazoles, benzothiazoles, amidines, antioxidative activity, antiproliferative activity
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Podaci o prilogu
143-143.
2021.
objavljeno
Podaci o matičnoj publikaciji
The 27th Croatian Meeting of Chemists and Chemical Engineers
Marković, Dean ; Meštrović, Ernest ; Namjesnik, Danijel ; Tomašić, Vesna
Zagreb: Hrvatsko kemijsko društvo
Podaci o skupu
27. hrvatski skup kemičara i kemijskih inženjera (27HSKIKI)
poster
05.10.2021-08.10.2021
Veli Lošinj, Hrvatska