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The associations between COMT and MAO-B genetic variants with negative symptoms in patients with schizophrenia (CROSBI ID 301253)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Madžarac, Zoran ; Tudor, Lucija ; Šagud, Marina ; Nedić Erjavec, Gordana ; Mihaljević Peleš, Alma ; Pivac, Nela The associations between COMT and MAO-B genetic variants with negative symptoms in patients with schizophrenia // Current issues in molecular biology, 43 (2021), 2; 618-636. doi: 10.3390/cimb43020045

Podaci o odgovornosti

Madžarac, Zoran ; Tudor, Lucija ; Šagud, Marina ; Nedić Erjavec, Gordana ; Mihaljević Peleš, Alma ; Pivac, Nela

engleski

The associations between COMT and MAO-B genetic variants with negative symptoms in patients with schizophrenia

Negative symptoms of schizophrenia, including anhedonia, represent a heavy burden on patients and their relatives. These symptoms are associated with cortical hypodopamynergia and impaired striatal dopamine release in response to reward stimuli. Catechol-O-methyltransferase (COMT) and monoamine oxidase type B (MAO-B) degrade dopamine and affect its neurotransmission. The study determined the association between COMT rs4680 and rs4818, MAO-B rs1799836 and rs6651806 polymorphisms, the severity of negative symptoms, and physical and social anhedonia in schizophrenia. Sex-dependent associations were detected in a research sample of 302 patients with schizophrenia. In female patients with schizophrenia, the presence of the G allele or GG genotype of COMT rs4680 and rs4818, as well as GG haplotype rs4818-rs4680, which were all related to higher COMT activity, was associated with an increase in several dimensions of negative symptoms and anhedonia. In male patients with schizophrenia, carriers of the MAO-B rs1799836 A allele, presumably associated with higher MAO-B activity, had a higher severity of alogia, while carriers of the A allele of the MAO-B rs6651806 had a higher severity of negative symptoms. These findings suggest that higher dopamine degradation, associated with COMT and MAO-B genetic variants, is associated with a sex-specific increase in the severity of negative symptoms in schizophrenia patients.

COMT ; MAO-B ; alogia ; anhedonia ; negative symptoms ; patients ; polymorphisms ; schizophrenia ; sex-differences

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

43 (2)

2021.

618-636

objavljeno

1467-3037

1467-3045

10.3390/cimb43020045

Povezanost rada

Kliničke medicinske znanosti

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