Cytotoxicity of harmiquines, hybrids based on harmine and chloroquine scaffolds (CROSBI ID 710852)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | domaća recenzija
Podaci o odgovornosti
Poje, Goran ; Held, Jana ; Rajić, Zrinka
engleski
Cytotoxicity of harmiquines, hybrids based on harmine and chloroquine scaffolds
Cancer, a disease characterized by uncontrolled growth of abnormal cells, is the second leading cause of death globally, accounting for an estimated 9.6 million deaths in 2018.[1] The emergence of cancer drug resistance remains a significant global public health and economic burden, emphasizing the need for new and effective anticancer agents. Herein, we represent harmiquines, hybrid compounds based on harmine and chloroquine, two moieties with confirmed anticancer properties.[2, 3] The cytotoxic potential of novel hybrids was examined in vitro against a panel of human cell lines (Hek293T, MCF-7, HepG2, SW620, HCT116). The cell growth rate was evaluated using the MTT assay with respect to untreated cells. Cytotoxicity, expressed as an IC50 value, was determined from concentration–response curve using nonlinear regression analysis. The compounds differentially affected the growth of tumor cell lines, whereby MCF-7 and HCT-116 cell lines appeared generally sensitive towards most of the tested compounds. Hybrids 1 and 2 (C-7-tethered derivatives) proved to be the most cytotoxic, affecting all tumor cell lines (IC50 values in the range of 1-8 μM) (Figure 1.). Harmiquine 3 exerted the most selective activity towards HepG2, in comparison to Hek293T (IC50 = 5.5 ± 3.2 uM, selectivity index > 9).
malaria, hybrid compounds, harmine, chloroquine, cytotoxicity
nije evidentirano
nije evidentirano
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nije evidentirano
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Podaci o prilogu
236-236.
2021.
objavljeno
Podaci o matičnoj publikaciji
27th Croatian Meeting of Chemists and Chemical Engineers, Book of Abstracts
Marković, Dean ; Meštrović, Ernest ; Namjesnik, Danijel ; Tomašić, Vesna
Zagreb: Hrvatsko kemijsko društvo
2757-0754
Podaci o skupu
27. hrvatski skup kemičara i kemijskih inženjera (27HSKIKI)
poster
05.10.2021-08.10.2021
Veli Lošinj, Hrvatska